Evidence map›Paper›PMID 42228537›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Mating-dependent lifespan cost of sterol depletion in male

Andrew W McCracken, Nicola White, Jola Tanianis-Hughes, Elena Rosca, Thomas Gill, Libby McKinney, Stephen J Simpson, Klaus Reinhardt, Marko Brankatschk, Matthew D W Piper and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mating-dependent lifespan cost of sterol depletion in maleProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew W McCrackenDepartment of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool CH64 7TE, United Kingdom.ORCID 0000-0001-8889-6275
Nicola WhiteDepartment of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool CH64 7TE, United Kingdom.ORCID 0000-0001-5800-4715
Jola Tanianis-HughesDepartment of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool CH64 7TE, United Kingdom.ORCID 0009-0007-7135-9239
Elena RoscaDepartment of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool CH64 7TE, United Kingdom.
Thomas GillDepartment of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool CH64 7TE, United Kingdom.
Libby McKinneyDepartment of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool CH64 7TE, United Kingdom.ORCID 0009-0004-2180-8196
Stephen J SimpsonCharles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales 2006, Australia.ORCID 0000-0003-0256-7687
Klaus ReinhardtApplied Zoology, Faculty of Biology, Technische Universität Dresden, Dresden 01069, Germany.
Marko BrankatschkPlant Cell and Molecular Biology, Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden 01217, Germany.
Matthew D W PiperFaculty of Science, School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia.ORCID 0000-0003-3245-7219
Juliano MorimotoSchool of Natural and Computing Science, Institute of Mathematics, School of Natural and Computing Sciences, University of Aberdeen, Aberdeen AB24 5PZ, United Kingdom.
Stuart WigbyDepartment of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool CH64 7TE, United Kingdom.ORCID 0000-0002-2260-2948

Funding

UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/V015249/1
6 · The paper itself

Abstract

Trade-offs between lifespan and reproduction are a central theme in evolution and ecology, often attributed to physiological constraints on the allocation of limiting resources. However, recent work suggests such trade-offs may depend on macro- and micronutritional context. We examined how macronutrient balance and cholesterol availability shape lifespan and reproductive performance in male

Indexed as

Drosophila melanogasterLongevitySexual Behavior, AnimalSterolsAnimalsCholesterolFemaleMaleReproductionCholesterolSterolsageingdietDrosophilanutritionreproduction

Identifiers

PMID42228537
PMCPMC13250600

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.