ArticleOrganic letters2026
Selective Electrochemical Defluorinative Hydroxymethylation toward Difluoro-Substituted Alcohol Building Blocks.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
Funding
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Abstract
Difluoromethylated compounds are of high importance for pharmaceutical and agrochemical industries; however, access to these structures remains limited due to the scarcity of reliable synthetic methods for their formation. This work presents a straightforward electrochemical synthesis of difluoromethyl-substituted alcohol building blocks via the selective monodefluorination of trifluoromethyl arenes with concomitant hydroxymethylation. The transformation proceeds with high chemoselectivity for a range of trifluoromethyl arene substrates under mild conditions. Mechanistic studies suggest that the reaction relies on reductive radical-polar crossover to furnish a key carbanion intermediate.
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Registered trials
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