ArticleNeuroImage. Clinical2026
Cerebellar structure is abnormal in schizophrenia and deviates from bipolar disorder.
Article in NeuroImage. Clinical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Stage-dependent effects of cognitive reserve on memory and brain structural integrity across the spectrum from healthy aging to Alzheimer's disease.Frontiers in human neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum has been implicated in schizophrenia-related structural and functional deficits, with posterior Crus I and II most consistently affected. Source-based morphometry (SBM) involves applying independent component analysis to gray matter volume to identify spatially distinct structural networks that covary across individuals. We applied SBM and voxel-based morphometry (VBM) to cerebellar structural imaging data to identify patterns of gray matter differences across individuals with schizophrenia (SZ), bipolar disorder with psychotic features (BDwP), and healthy controls (HC). Data were drawn from the Psychosis Human Connectome Project (P-HCP) and included 168 participants: 85 with SZ, 36 with BDwP, and 47 HC. T1-weighted images were processed using the ENIGMA Cerebellum Volumetrics Pipeline, and ICA decompositions were performed using the SBM module of the GIFT Toolbox. One independent component (IC) showed a significant diagnostic group effect (p < 0.05, Bonferroni-corrected), differentiating SZ from HC and BDwP. This cerebellar network included vermis VIIIa, bilateral Crus I, and right lobule IX with positive loadings, and bilateral Crus I and lobule IX with negative loadings. Voxel-based morphometry showed reduced GM volume in negatively loaded regions in SZ. Composite cognitive performance correlated with GM volume (r = 0.27, p < 0.001) and network loadings (r = -0.29, p < 0.001). Mediation analyses showed a strong direct diagnostic effect on IC loadings (-0.42), with small, nonsignificant indirect effects via cognition. These findings identify a cerebellar structural network that differentiates schizophrenia from bipolar disorder and controls, underscoring the cerebellum's unique contribution to the neurobiology of schizophrenia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.