Evidence map›Paper›PMID 42229423›Full record

ArticleCell2026

Plant cell wall-plasma membrane attachments mediate stress resilience through cellulose synthase complexes and remorins.

Yue Rui, Magda Zaoralová, William P Dwyer, Andres V Reyes, Tarabryn S Grismer, Nikolaj B Abel, Dharanidaran Jayachandran, Shishir P S Chundawat, Thomas Ott, Joseph J Kieber and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yue RuiDepartment of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: yuerui@stanford.edu.
Magda ZaoralováSLAC National Accelerator Laboratory, Department of Photon Science and Structural Biology, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
William P DwyerDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Andres V ReyesDivision of Biosphere Science and Engineering, Carnegie Institution for Science, Stanford, CA 94305, USA; Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA 94305, USA.
Tarabryn S GrismerDivision of Biosphere Science and Engineering, Carnegie Institution for Science, Stanford, CA 94305, USA; Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA 94305, USA.
Nikolaj B AbelDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus 8000, Denmark.
Dharanidaran JayachandranDepartment of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Shishir P S ChundawatDepartment of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Thomas OttFaculty of Biology, University of Freiburg, Freiburg 79104, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg 79104, Germany.
Joseph J KieberDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Peter D DahlbergSLAC National Accelerator Laboratory, Department of Photon Science and Structural Biology, Stanford University, Stanford, CA 94305, USA.
Shou-Ling XuDivision of Biosphere Science and Engineering, Carnegie Institution for Science, Stanford, CA 94305, USA; Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA 94305, USA.
José R DinnenyDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: dinneny@stanford.edu.

Funding

Signaling in cell expansion and morphogenesisR01GM123259 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI DINNENY, JOSE R, EHRHARDT, DAVID W · 2017 to 2020
$1.9M
Thermo Orbitrap Eclipse Tribrid with ETD and an Ultimate 3000 RSLCnano SystemS10OD030441 · OD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2022 to 2022
$600k
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM123259NIH HHS S10 OD030441
6 · The paper itself

Abstract

The outer cell surface of an organism is the frontline for detecting and responding to environmental stimuli. In plants, this interface consists of the plasma membrane that lies beneath the cell wall and remains associated with it through attachment sites. These wall-membrane attachments become evident upon hyperosmotic shock, when severe water loss causes the membrane to retract from the wall. Despite their long-standing observation, the molecular identity and function of these attachments remain poorly understood. Here, we identified two mechanisms governing wall-membrane attachments: one dependent on the cellulose synthase complex (CSC), whose density at the plasma membrane positively correlates with resistance to hyperosmotic stress, and the other on remorin (REM), which acts antagonistically to the CSC mechanism. Using proximity-labeling proteomics, we identified SHOU4/4L as REM-associated proteins that mediate this antagonism. Together, our findings reveal how wall-membrane attachments are patterned to mediate plant cell resilience under water stress.

Indexed as

ArabidopsisArabidopsis ProteinsCarrier ProteinsCell MembraneCell WallGlucosyltransferasesOsmotic PressurePlant ProteinsStress, PhysiologicalArabidopsis ProteinsCarrier Proteinscellulose synthaseGlucosyltransferasesPlant Proteinsremorin

Identifiers

PMID42229423
PMCPMC13270924

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.