Evidence map›Paper›PMID 42230302›Full record

Trial reportEuropean journal of sport science2026

The Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes.

Chloe Masters, Ajmol Ali, Claire Badenhorst, Martin Dickens, Kay Rutherfurd-Markwick

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of sport science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chloe MastersSchool of Sport, Exercise and Nutrition, Massey University, North Shore City, New Zealand.
Ajmol AliSchool of Sport, Exercise and Nutrition, Massey University, North Shore City, New Zealand.ORCID https://orcid.org/0000-0002-6093-1435
Claire BadenhorstEast Metropolitan Health Service, Edith Cowan University, Perth, Western Australia, Australia.
Martin DickensSchool of Health Sciences, Massey University Albany, North Shore City, New Zealand.
Kay Rutherfurd-MarkwickSchool of Health Sciences, Massey University Albany, North Shore City, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined the effects of caffeine consumption on endurance exercise performance, and the influence of CYP1A2 gene polymorphisms in caffeine pharmacokinetics and exercise performance. The data sets of two randomised, double blind, placebo-controlled crossover study design experiments have been merged. Thirty-eight recreationally active male participants provided saliva samples for CYP1A2 genotyping (AA homozygotes n = 19; AC heterozygotes n = 19) and completed either a 10-km run or 40-km cycling time trial of 60-min following a single dose of 6 mg·kg

Indexed as

Athletic PerformanceCaffeineCytochrome P-450 CYP1A2Polymorphism, GeneticAdultAthletesCross-Over StudiesDouble-Blind MethodGenotypeHeart RateHumansMalePhysical EnduranceRunningTheophyllineYoung AdultCaffeineCYP1A2 protein, humanCytochrome P-450 CYP1A2Theophyllineathleteendurance exercisegeneticsphysical activitysport

Identifiers

PMID42230302
PMCPMC13239719

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.