Observational studyChinese medical journal2026
Association of long-term exposure to lower low-density lipoprotein cholesterol with neuroimaging metrics: A population-based cohort study.
Observational study in Chinese medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05453877 (Clinical Indicators and Brain Image Data), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Indicators and Brain Image Data: a Cohort Study Based on Kailuan Cohort
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited evidence exists regarding the relationship between long-term exposure to low concentrations of low-density lipoprotein cholesterol (LDL-C) and brain structural integrity. This study aimed to examine the associations of cumulative low LDL-C exposure with a series of neuroimaging metrics.
methodsThis study included 987 participants (median age 55 years) from a population-based cohort study in China. Serum circulatory LDL-C concentrations were assessed biennially from 2006 to 2018. Prolonged LDL-C exposure was calculated using a time-weighted average (TWA) approach during that period. Brain MRI examinations were performed during 2020-2022. We used generalized linear model to investigate the multivariate-adjusted associations of TWA LDL-C levels with MRI markers of brain tissue volume, white matter microstructural integrity, and white matter hyperintensity (WMH).
resultsAfter full adjustments, TWA LDL-C concentrations of 70-100 mg/dL and less than 70 mg/dL were associated with lower fractional anisotropy value and higher mean diffusivity, axial diffusivity, and radial diffusivity value compared to LDL-C concentrations of 100-130 mg/dL. These associations were particularly prominent in male participants and older participants who were over 50 years. No association was found between relatively lower LDL-C levels and brain tissue volumes or WMH.
conclusionLDL-C concentrations of 70-100 mg/dL and <70 mg/dL are associated with impaired microstructural integrity of brain white matter.
trial registrationhttps://clinicaltrials.gov/ , NCT05453877.
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