Evidence map›Paper›PMID 42230421›Full record

ArticleBiological trace element research2026

Chronic Arsenic Exposure Induced Reproductive Toxicity by Promoting Ferroptosis and the Protective Effects of Xylo-Oligosaccharides.

Xin Jiang, Yuanbin Wang, Jianyu Qu, Ying Ma, Xin Sheng, Jine Yi, Ji Wang, Lixin Wen, Rongfang Li, Shuiping Liu

Abstract read
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In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin JiangHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China.
Yuanbin WangHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China.
Jianyu QuHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China.
Ying MaHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China.
Xin ShengHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China.
Jine YiHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China.
Ji WangHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China.
Lixin WenHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China.
Rongfang LiHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China. lrf0408@126.com.
Shuiping LiuHunan Engineering and Technology Research Centre for Livestock and Poultry Health Care, College of Animal Medicine, Hunan Agricultural University, Changsha, Hunan Province, China. liushuiping@hunau.edu.cn.

Funding

Horizontal Topics of Hunan Agricultural University 2019xny-js044Hunan Provincial Department of Education 24B0204Natural Science Foundation of Changsha kq2402116
6 · The paper itself

Abstract

Arsenic, a toxic metalloid widespread in groundwater, induces multi-organ damage upon chronic exposure. The male reproductive system, which is crucial for species propagation, requires a stable testicular microenvironment to function properly. Although the reproductive system is recognized as one of the most sensitive targets of arsenic toxicity, the underlying molecular mechanisms and effective intervention strategies remain incompletely understood. In this study, we systematically evaluated the impact of chronic arsenic exposure on testicular function in male C57BL/6J mice administered sodium arsenite (NaAsO₂) in their drinking water for six months. Our results found that chronic arsenic exposure decreased sperm quality, induced testicular oxidative stress and inflammation, and caused the blood-testicular barrier(BTB) injury in mice. Meanwhile, chronic arsenic exposure increased the Fe²⁺ content and the levels of ferroptosis-related mRNA/protein, and decreased the mRNA/protein levels of Nrf2/GPX4 signaling pathway in the testis. Notably, supplementation with Xylo-oligosaccharides (XOS) derived from Miscanthus lutarioriparius effectively alleviated the arsenic-induced decline in sperm quality, testicular damage, oxidative stress and inflammation. Further mechanistic investigation revealed that XOS exerts its protective effects by activating the Nrf2/GPX4 signaling pathway in the testes, thereby inhibiting the ferroptosis process. Overall, our findings provide a potential preventive strategy against arsenic-induced male reproductive injury.

Indexed as

ArsenicArsenitesFerroptosisOligosaccharidesProtective AgentsSodium CompoundsTestisAnimalsMaleMiceMice, Inbred C57BLNF-E2-Related Factor 2Oxidative StressReproductionArsenicArsenitesNF-E2-Related Factor 2OligosaccharidesProtective Agentssodium arseniteSodium CompoundsArsenicFerroptosisOxidative stressProductive disordersTesticular damageXylo-oligosaccharides

Identifiers

PMID42230421

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.