Evidence map›Paper›PMID 42230490›Full record

ArticleBulletin of experimental biology and medicine2026

3-Acetylpyridine Induced Changes in the Cerebellar Purkinje Cells.

D N Voronkov, A V Stavrovskaya, K A Kutukova, I A Potapov, A S Romanenko, A K Pavlova, M V Ivanov, S N Illarioshkin

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

D N VoronkovRussian Center of Neurology and Neurosciences, Moscow, Russia. voronkov@neurology.ru.
A V StavrovskayaRussian Center of Neurology and Neurosciences, Moscow, Russia.
K A KutukovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
I A PotapovRussian Center of Neurology and Neurosciences, Moscow, Russia.
A S RomanenkoRussian Center of Neurology and Neurosciences, Moscow, Russia.
A K PavlovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
M V IvanovRussian Center of Neurology and Neurosciences, Moscow, Russia.
S N IllarioshkinRussian Center of Neurology and Neurosciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraperitoneal administration of 3-acetylpyridine (3-AP) to rodents has previously been proposed for modeling cerebellar degeneration. However, morphological descriptions of changes in the cerebellar Purkinje cells (PCs) are fragmentary. In this work, changes in PCs in rats after 3-AP intoxication were characterized using immunomorphological methods and electron microscopy. Administration of 3-AP caused severe motor disturbances associated with damage, loss, and abnormal distribution of PCs containing aldolase C and a marked decrease in the level of cytochrome oxidase in PCs and synaptophysin in the cerebellar glomeruli. At the ultrastructural level, changes in the PCs of the "dark type" were observed. These results allow us to consider administration of 3-AP as a model of spinocerebellar ataxia reproducing motor disturbances and morphological changes in the cerebellar cortex.

Indexed as

Purkinje CellsPyridinesAnimalsCerebellumElectron Transport Complex IVFructose-Bisphosphate AldolaseMaleRatsRats, WistarSynaptophysin3-acetylpyridineElectron Transport Complex IVFructose-Bisphosphate AldolasePyridinesSynaptophysin3-acetylpyridinecerebellar ataxiaPurkinje cells

Identifiers

PMID42230490

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.