Changes in the Expression Levels of Hypoxia-Inducible Factor Isoforms and Their Regulating microRNAs in Peripheral Blood Leukocytes after Hypoxic Exposure in Wistar Rats with Different Tolerance to Oxygen Deficiency.

M V Kirillova, D Sh Dzhalilova, O V Makarova

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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5 · Who and what money

Authors and funding

3 authors.

M V KirillovaPetrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia. marusyasilina99@yandex.ru.

D Sh DzhalilovaPetrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia.

O V MakarovaPetrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following a single, severe hypoxic exposure (7000 m, 1 h), changes in the expression levels of Hif1a, Epas1 (Hif2a), and Hif3a mRNA, as well as miR-210, miR-107, miR-145, and miR-155 microRNAs in peripheral blood leukocytes were assessed in hypoxia-tolerant (HT) and hypoxia-susceptible (HS) male Wistar rats. HT animals exhibited a significant 148% increase in Epas1 expression, and HS animals demonstrated a 142% increase in Hif3a expression. Reduced expression levels of rno-miR-210-3p, rno-miR-145-3p, and rno-miR-155-3p in HT rats and increased expression of rno-miR-107-5p in HS rats were also detected. These differences confirm previous data obtained in in vitro and in vivo experiments and indicate a more pronounced adaptive response to oxygen deficiency in HS animals.

Indexed as

Basic Helix-Loop-Helix ProteinsHypoxiaHypoxia-Inducible Factor 1, alpha SubunitLeukocytesMicroRNAsOxygenAnimalsEndothelial PAS Domain-Containing Protein 1Gene Expression RegulationMaleProtein IsoformsRatsRats, WistarRNA, MessengerBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Hif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsOxygenProtein IsoformsRNA, Messengerbiomarkershypoxia-inducible factorhypoxia tolerancehypoxic exposuremicroRNA

Identifiers

PMID42230501

DOI10.1096/fj.14-26705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.