Evidence map›Paper›PMID 42230578›Full record

ArticleNature communications2026

HPV16 genetic variation provides evidence of positive natural selection driven by HLA class I.

Chase W Nelson, Sambit K Mishra, Michael Dean, Colm Ohuigin, Robert D Burk, Bin Zhu, Difei Wang, Laurie Burdett, Mathias Viard, Hyo Jung Lee and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Chase W NelsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. chase.nelson@nih.gov.ORCID http://orcid.org/0000-0001-6287-1598
Sambit K MishraDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.ORCID http://orcid.org/0000-0001-8319-0599
Michael DeanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.ORCID http://orcid.org/0000-0003-2234-0631
Colm OhuiginBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Robert D BurkDepartments of Pediatrics, Epidemiology and Population Health, Microbiology and Immunology, and Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8376-8458
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.ORCID http://orcid.org/0000-0003-0172-5516
Difei WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.ORCID http://orcid.org/0000-0003-4088-3859
Laurie BurdettDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Mathias ViardBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Hyo Jung LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Aimee J KoestlerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.ORCID http://orcid.org/0009-0002-4983-3997
Apurva NarechaniaInstitute for Comparative Genomics, American Museum of Natural History, New York, NY, USA.
Zigui ChenDepartment of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-8577-1298
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.ORCID http://orcid.org/0000-0003-1251-0836
Mark SchiffmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Gary M CliffordEarly Detection, Prevention and Infections Branch, International Agency for Research on Cancer, Lyon, France.ORCID http://orcid.org/0000-0001-7534-333X
Elizabeth Suh-BurgmannDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.ORCID http://orcid.org/0000-0003-4732-1453
Thomas LoreyRegional Laboratory and Women's Health Research Institute, Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-2692-2180
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.ORCID http://orcid.org/0000-0003-3871-2225
Lisa MirabelloDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. mirabellol@mail.nih.gov.ORCID http://orcid.org/0000-0001-8485-0106

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2M
Investigations Into The Molecular Pathogenesis Of Cervical Glandular NeoplasiasU01CA238592 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BURK, ROBERT D, STRICKLER, HOWARD D · 2020 to 2024
$2.8M
NCI NIH HHS P30 CA013330NCI NIH HHS U01 CA238592NIH HHS 75N91019D00024Wellcome Trust
6 · The paper itself

Abstract

Human papillomavirus type 16 (HPV16) causes more cancer than any other virus. However, most HPV16 infections are controlled by the host's immune system and it remains unclear how viral and host genetic variation contribute to infection outcomes. Here, we analyze 4704 HPV16 whole genomes to identify 56 viral codons putatively under positive natural selection to change their amino acids, with evidence including d

Indexed as

Genetic VariationHistocompatibility Antigens Class IHuman papillomavirus 16Selection, GeneticCodonEvolution, MolecularGenome, ViralHumansOncogene Proteins, ViralPapillomavirus InfectionsCodonHistocompatibility Antigens Class IOncogene Proteins, Viral

Identifiers

PMID42230578
PMCPMC13392105

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.