Evidence map›Paper›PMID 42230596›Full record

ArticleNature communications2026

Decreased degree of adipocyte differentiation in visceral adipose tissue contributes to metabolic dysfunction-associated steatotic liver disease.

Kyla Z Gelev, Seung Hyuk T Lee, Marcus Alvarez, Rosellina M Mancina, Federica Tavaglione, Oveis Jamialahmadi, Umberto Vespasiani-Gentilucci, Asha Kar, Zitian Wang, Dorota Kaminska and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kyla Z GelevDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3980-7189
Seung Hyuk T LeeDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0943-6076
Marcus AlvarezDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Rosellina M MancinaDepartment of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy.ORCID http://orcid.org/0000-0002-1126-3071
Federica TavaglioneResearch Unit of Clinical Medicine and Hepatology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.ORCID http://orcid.org/0000-0002-1720-4355
Oveis JamialahmadiCentre for Reproduction, Metabolism and Molecular medicine (CeRM), Department of Medicine (H7), Karolinska Institute, Huddinge, Sweden.ORCID http://orcid.org/0000-0001-7139-4738
Umberto Vespasiani-GentilucciResearch Unit of Clinical Medicine and Hepatology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Asha KarDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0000-1717-1744
Zitian WangDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Dorota KaminskaDivision of Cardiology, Department of Medicine, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1829-576X
Minna U KaikkonenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0001-6294-0979
Ville MännistöInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Sini HeinonenDepartment of Internal Medicine and Rehabilitation, Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-6342-0577
Tuure SaarinenDepartment of Abdominal Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7508-4849
Anne JuutiDepartment of Abdominal Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-8522-1288
Jussi PihlajamäkiInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. jussi.pihlajamaki@uef.fi.ORCID http://orcid.org/0000-0002-6241-6859
Stefano RomeoCentre for Reproduction, Metabolism and Molecular medicine (CeRM), Department of Medicine (H7), Karolinska Institute, Huddinge, Sweden. stefano.romeo@ki.se.ORCID http://orcid.org/0000-0001-9168-4898
Päivi PajukantaDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. PPajukanta@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-6423-8056

Funding

Multimodal omics approach to identify health to cardiometabolic disease transitionsR01HL170604 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Paivi Pajukanta · 2023 to 2026
$2.8M
Genetics of adipose cell-type expression and cardiometabolic traitsR01DK132775 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOHLKE, KAREN L., PAJUKANTA, PAIVI · 2022 to 2025
$2.4M
Discovering mechanisms of metabolic dysfunction-associated steatotic liver disease in cell-type and cellular subtypes of multiple metabolic tissuesF31DK146422 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kyla Zagorah Gelev · 2026 to 2026
$43k
Cancerfonden (Swedish Cancer Society) 22 2270 PjNHLBI NIH HHS R01 HL170604NIDDK NIH HHS F31 DK146422NIDDK NIH HHS R01 DK132775Sigrid Juséliuksen Säätiö (Sigrid Jusélius Foundation) 101115381Sydäntutkimussäätiö (Finnish Foundation for Cardiovascular Research) 101125115U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL170604U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) F31DK146422U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK132775Vetenskapsrådet (Swedish Research Council) 2023-02079
6 · The paper itself

Abstract

The mechanisms connecting the human fat depots, subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), to metabolic dysfunction-associated steatotic liver disease (MASLD) remain elusive. We hypothesize that in individuals with obesity, a decreased degree of adipocyte differentiation may contribute to ectopic fat accumulation in the liver, seen in MASLD. Here we show, using single nucleus RNA-sequencing from adipose tissue biopsies, that the predicted degree of VAT adipocyte differentiation is decreased in individuals with MASLD, with an attenuated impact observed in SAT adipocytes. Next, we discover that regional variants of the VAT adipocyte differentiation gene set explain a substantial proportion (17%) of MASLD heritability. These genes largely overlap (>50%) with adipocyte genes differentially expressed by MASLD, regulated by variants in cis. Finally, we show that these genes are linked to smaller adipocyte size. Together, our findings reveal that a decreased predicted degree of VAT adipocyte differentiation contributes to MASLD.

Indexed as

AdipocytesCell DifferentiationFatty LiverIntra-Abdominal FatNon-alcoholic Fatty Liver DiseaseFemaleHumansLiverMaleMiddle AgedObesitySubcutaneous Fat

Identifiers

PMID42230596
PMCPMC13392065

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.