Evidence map›Paper›PMID 42230677›Full record

ArticleScientific reports2026

Fluorine-19 MRI signal phenotype in solid tumor following in situ perfluorocarbon cell labeling.

Eric T Ahrens, Keith Tang, Giuliana P Mognol, Hui Chen, Benjamin I Leach, Andrew Davis, Judith Varner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric T AhrensDepartment of Radiology, University of California, San Diego, 9500 Gilman Dr. #0695, La Jolla, CA, 92093-0695, USA. eta@ucsd.edu.
Keith TangDepartment of Radiology, University of California, San Diego, 9500 Gilman Dr. #0695, La Jolla, CA, 92093-0695, USA.
Giuliana P MognolDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Hui ChenDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Benjamin I LeachGondolaBio, Palo Alto, CA, USA.
Andrew DavisDepartment of Radiology, University of California, San Diego, 9500 Gilman Dr. #0695, La Jolla, CA, 92093-0695, USA.
Judith VarnerDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.

Funding

Role of PI3Kinase in Tumor Progression and MetastasisR01CA167426 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Judith A VARNER · 2012 to 2026
$5.8M
Therapeutic Targeting of Macrophage PI3Kgamma in HNSCCR01CA226909 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kathryn Ann Gold, Judith A VARNER · 2018 to 2026
$3.9M
10X Chromium Connect for Single Cell Library Preparations for Translational ResearchS10OD032398 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARNER, JUDITH A · 2022 to 2022
$284k
NCI NIH HHS R01 CA167426NCI NIH HHS R01 CA226909NIH HHS S10 OD032398
6 · The paper itself

Abstract

Cell tracking with perfluorocarbon (PFC) nanoemulsion (NE) and ¹⁹F MRI has been used in numerous inflammation models, including tumors. After intravenous injection, phagocytic immune cells endocytose NE droplets, producing background-free ¹⁹F images where signal foci quantify inflammation. Histology confirms tracer uptake mainly in myeloid-lineage cells. Myeloid cells - granulocytes, monocytes, and macrophages - play major roles in cancer. Tumor-associated macrophages (TAMs), which can comprise up to 60% of tumor mass, promote angiogenesis, metastasis, and immunosuppression. High TAM burden correlates with poor prognosis in several cancers and reduced responsiveness to immunotherapies. In this study, we characterize ¹⁹F MRI signals, following in situ NE labeling, in a syngeneic breast cancer model. Our goal is to validate the cell phenotype responsible for the

Indexed as

Cell TrackingFluorine-19 Magnetic Resonance ImagingFluorocarbonsAnimalsCell Line, TumorFemaleFluorineMacrophagesMicePhenotypeTumor-Associated MacrophagesTumor MicroenvironmentFluorineFluorocarbonsFluorine-19InflammationMacrophageMRINanoemulsionPerfluorocarbon

Identifiers

PMID42230677
PMCPMC13470017

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.