Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Heather VolkDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Christine Ladd-AcostaDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7697-3998
Nilanjan ChatterjeeDepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. nilanjan@jhu.edu.ORCID http://orcid.org/0000-0002-9060-008X
Funding
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
PHENOTYPE AND GENETICS IN OROFACIAL CLEFT FAMILIESP50DE016215 · NIDCR · UNIVERSITY OF IOWA · PI FITZPATRICK, DAVID · 2004 to 2008
$10.1M
GEARs Combining advances in Genomics and Environmental science to accelerate Actionable Research and practice in ASDR01ES034554 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Christine Ladd-Acosta, HEATHER E VOLK · 2022 to 2026
$9.7M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Molecular Genetic Epidemiology of Cleft Lip and PalateR37DE008559 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2004 to 2013
$6.8M
International Genetic Epidemiology of Oral CleftsR01DE014581 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI BEATY, TERRI H · 2004 to 2013
$6.6M
Genome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6M
Enabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5M
SNP DISCOVERY AND ANALYSIS IN CRANIOFACIAL BIRTH DEFECTSR01DE013939 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI SCOTT, ALAN F · 2000 to 2004
$4.3M
Robust Methods for Polygenic Analysis to Inform Disease Etiology and Enhance Risk PredictionR01HG010480 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI CHATTERJEE, NILANJAN · 2019 to 2023
$2.8M
NCI NIH HHS U01 CA249866NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS R00 HG013674NHGRI NIH HHS R01 HG010480NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG011719NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NIDCR NIH HHS P50 DE016215NIDCR NIH HHS R01 DE009886NIDCR NIH HHS R01 DE013939NIDCR NIH HHS R01 DE014581NIDCR NIH HHS R01 DE016148NIDCR NIH HHS R01 DE031855NIDCR NIH HHS R21 DE016930NIDCR NIH HHS R37 DE008559NIDCR NIH HHS U01 DE018993NIEHS NIH HHS R01 ES034554NIGMS NIH HHS R35 GM150836NIH HHS U24 OD023382U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) 1R01HG010480U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R00HG013674U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) U01HG011719U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE031855U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) R01ES034554U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM150836U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) U01CA249866U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) 1U24OD023382
6 · The paper itself
Abstract
We have proposed PGS-TRI, a framework for analyzing polygenic scores (PGSs) in case-parent trio studies that estimate the risk of an index condition associated with direct PGS effects, gene-environment interactions and asymmetrical maternal and paternal indirect effects. Simulations confirm its robustness in the presence of complex population structure and assortative mating. Applied to multi-ancestry autism spectrum disorders (ASD) trios (n
Indexed as
Autism Spectrum DisorderGene-Environment InteractionMultifactorial InheritanceChildCleft PalateFemaleGenetic Risk ScoreGenome-Wide Association StudyHumansModels, GeneticParentsPolymorphism, Single Nucleotide
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Estimation of direct and indirect polygenic effects and gene-environment interactions using polygenic scores in case-parent trio studies. · full record | Socratic