ReviewNature reviews. Molecular cell biology2026
Caveolae mechanics in cellular functions and disease.
Review in Nature reviews. Molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caveolae are small, cup-shaped invaginations of the plasma membrane that are enriched in caveolin and cavin proteins, cholesterol and glycosphingolipids. These specialized nanodomains serve diverse functions across numerous cell types; for example, they regulate nitric oxide signalling and transcytosis in endothelial cells, whereas in adipocytes and muscle cells they contribute to lipid homeostasis and mechanoprotection. In this Review, we highlight recent advances in caveolae biology, with a particular focus on structural insights from super-resolution microscopy and high-resolution cryo-electron microscopy of caveolin oligomers. We examine the molecular organization and resting-state dynamics of caveolar components, and explore how their metastable architecture enables rapid disassembly in response to mechanical and biochemical stimuli. We focus on caveolae-mediated mechanosensing, membrane protection and mechanotransduction, discussing how caveolae mechanics govern key cellular processes and interface with other mechanosensitive systems. Finally, we examine emerging evidence linking impaired caveolae mechanosensitivity to a variety of pathologies, and discuss how a deeper understanding of caveolae mechanics may inform the development of novel diagnostic and therapeutic strategies.
Indexed as
Identifiers
42230980What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.