ArticleNature aging2026
Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.
Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Time-restricted feeding puts mouse healthspan on the clock.Nature aging · 2026Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Time-restricted feeding (TRF) aligned with an organism's circadian rhythm has been shown to improve health, but its long-term effects on healthspan and lifespan in mammals, especially under standard dietary conditions that do not promote obesity, remain unclear. Here, we examined the impact of 12-h and 8-h nightly TRF windows in 264 male and 264 female C57BL/6 J mice fed regular chow. TRF improved multiple health measures, including behavioral rhythmicity, body weight and composition, frailty, and disease onset. These effects were most pronounced in the 8-h TRF group, which exhibited voluntary caloric restriction in addition to time restriction. A composite Healthspan Index revealed that TRF extended healthspan in both sexes, though the benefits were more prolonged in female mice relative to their total lifespan. Median lifespan was significantly extended in male mice under 8-h TRF by 12%, whereas female mice showed no significant lifespan extension. These results demonstrate sex-specific effects of TRF on mammalian aging.
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