Evidence map›Paper›PMID 42231021›Full record

ArticleNature neuroscience2026

Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility.

Valentina N Lagomarsino, Ariel Robinson, Perry E Mitchell, Mira Jiang, Lauren E Hutchinson, Josh John Sekela, Patrick Caron, McKenzie K Gehris, Kathleen I Navas, Murillo Duarte-Silva and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Valentina N LagomarsinoDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3195-1899
Ariel RobinsonDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Perry E MitchellDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Mira Jiang *Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Lauren E Hutchinson *Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0009-0008-1712-7186
Josh John Sekela *Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Patrick Caron *Pharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec Research Center -Université Laval, Faculty of Pharmacy, Université Laval, Quebec, Quebec, Canada.
McKenzie K GehrisDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-1995-1442
Kathleen I NavasDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Murillo Duarte-SilvaDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Michael NetherlandEzBiome Inc., Gaithersburg, MD, USA.
Nur A HasanEzBiome Inc., Gaithersburg, MD, USA.
Chantal GuillemettePharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec Research Center -Université Laval, Faculty of Pharmacy, Université Laval, Quebec, Quebec, Canada.ORCID http://orcid.org/0000-0002-1113-1212
Matthew R RedinboDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-0814-5346
Meenakshi RaoDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. meenakshi.rao@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-8194-9204

Funding

Microbial reactivation of sex steroids and visceral painR01DK130836 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Meenakshi Rao · 2022 to 2026
$2.7M
Isoform- and Sex-Specific Functions of CGRP in Gastrointestinal MotilityR01DK135707 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Meenakshi Rao · 2023 to 2026
$2.6M
Gut Microbial Enzymes and Human DiseaseR35GM152079 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Matthew R Redinbo · 2024 to 2026
$1.6M
Structural Basis for Hormone and Neurotransmitter Processing by Gut Microbial EnzymesR01GM135218 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2019 to 2022
$1.5M
Androgen Regulation of Colonic MotilityR03DK125636 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI RAO, MEENAKSHI · 2020 to 2021
$266k
NIDDK NIH HHS R01 DK130836NIDDK NIH HHS R01 DK135707NIDDK NIH HHS R03 DK125636NIGMS NIH HHS R01 GM135218NIGMS NIH HHS R35 GM152079U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK130836U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK135707U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R03DK125636U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM135218U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM152079
6 · The paper itself

Abstract

The coordinated transit of intestinal contents is crucial for digestion and host defense, and is regulated by cross-talk between neural circuits, the muscular gut wall and luminal factors. Here we show that androgen signaling to Nos1

Indexed as

AndrogensEnteric Nervous SystemGastrointestinal MicrobiomeGastrointestinal MotilityNeuronsAnimalsGlucuronidaseHumansMaleMiceMice, Inbred C57BLNitric Oxide Synthase Type IReceptors, AndrogenTestosteroneAndrogensGlucuronidaseNitric Oxide Synthase Type INos1 protein, mouseReceptors, AndrogenTestosterone

Identifiers

PMID42231021
PMCPMC13403785

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.