Evidence map›Paper›PMID 42231109›Full record

ArticleEnvironmental science & technology2026

Prenatal PFAS Exposure in a Twin Pregnancy Cohort: Associations with Thyroid Disruption, Placental Malperfusion, and Fetal Growth Restriction.

Heeyeon Chae, Eun Na Kim, Na-Youn Park, Inae Lee, Young Ah Lee, Jong Kwan Jun, Gi Jeong Cheon, Young Joo Park, Younglim Kho, Sun Wook Cho and 1 more

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In one paragraph

Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heeyeon ChaeGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of South Korea.
Eun Na KimDepartment of Pathology, Seoul National University Hospital, Seoul 03080, Republic of South Korea.
Na-Youn ParkDepartment of Health, Environment & Safety, Eulji University, Seongnam, Gyeonggi-do 13135, Republic of South Korea.
Inae LeeDepartment of Public Health, Keimyung University, Daegu 42601, Republic of Korea.
Young Ah LeeDepartment of Pediatrics, Seoul National University Children's Hospital and Seoul National University College of Medicine, Seoul 03080, Republic of South Korea.
Jong Kwan JunDepartment of Obstetrics and Gynecology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul 03080, Republic of South Korea.
Gi Jeong CheonDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Young Joo ParkDepartment of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Younglim KhoDepartment of Health, Environment & Safety, Eulji University, Seongnam, Gyeonggi-do 13135, Republic of South Korea.ORCID 0000-0002-2590-4722
Sun Wook ChoDepartment of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Kyungho ChoiGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of South Korea.ORCID 0000-0001-7460-792X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Twin pregnancies are particularly vulnerable to chemical exposures such as per- and polyfluoroalkyl substances (PFAS), yet mechanistic evidence linking PFAS to adverse pregnancy outcomes remains limited. In this study, we examined maternal and cord serum PFAS exposure in relation to thyroid function, placental pathology, and fetal growth in a subset of twins from the Ideal Breastmilk (IBM) cohort in Korea (78 mothers, 199 neonates). Cord serum PFAS exposure was associated with a thyroid hormone profile characterized by higher FT4 and lower TSH within the reference range. In addition, higher cord PFOA, PFNA, and ∑PFCA concentrations were associated with lower birth weight. Maternal concentrations of these PFAS were highest in pregnancies with severe placental malperfusion (maternal vascular underperfusion, MVU). Placental gene expression analysis revealed reduced

Indexed as

Fetal Growth RetardationFluorocarbonsCohort StudiesFemaleHumansMaternal ExposurePlacentaPregnancyPregnancy, TwinThyroid GlandFluorocarbonsbirth weightPFASplacentathyroid hormonestwin pregnancy

Identifiers

PMID42231109
PMCPMC13276900

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.