ArticleBMC surgery2026
Analysis of medium-term prognostic factors for laparoscopic radical resection of serosal infiltrating (pT4a) gastric cancer: a retrospective cohort study.
Article in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the clinicopathological characteristics and factors influencing medium-term prognosis in patients with gastric cancer and serosal invasion (pT4a) following laparoscopic radical gastrectomy.
methodsIn this retrospective study, 461 patients with pT4a gastric cancer who underwent laparoscopic D2 radical gastrectomy at The First Affiliated Hospital of Shandong Second Medical University (October 2019-December 2024) were analyzed. Survival was assessed by the Kaplan-Meier method; prognostic factors were identified using univariate and multivariate Cox regression.
resultsPoorly differentiated/undifferentiated adenocarcinoma comprised 76.8% of cases, and 63.8% were of the diffuse Lauren type. Median tumor diameter was 5.5 cm (58.2% >5 cm). Lymphovascular and perineural invasion were present in 88.7% and 92.4% of patients, respectively; tumor deposits were found in 10.7%. Overall lymph node metastasis rate was 84.8% (pN3a: 25.2%, pN3b: 19.5%). With a median follow-up of 26.0 months, median overall survival (OS) was 49.0 months and median disease-free survival (DFS) was 37.0 months. Multivariate analysis identified independent adverse prognostic factors for OS: age (HR = 1.03, 95% CI 1.01-1.04, P = 0.001), elevated CA19-9 (HR = 1.58, 95% CI 1.15-2.17, P = 0.004), tumor deposits (HR = 1.40, 95% CI 1.01-1.94, P = 0.045), Lauren classification (HR = 1.32, 95% CI 1.04-1.68, P = 0.022), total gastrectomy (vs. partial/subtotal; HR = 1.81, 95% CI 1.35-2.43, P < 0.001), and advanced pN stage (HR = 1.54, 95% CI 1.26-1.88, P < 0.001). For DFS, independent predictors were age, elevated CA19-9, tumor deposits, total gastrectomy, and pN stage (all P < 0.05).
conclusionIn this study cohort, patients with pT4a gastric cancer who underwent laparoscopic D2 radical resection achieved medium-term survival outcomes that are broadly comparable to those reported in historical open surgery cohorts. Age, elevated CA19-9, tumor deposits, Lauren classification(diffuse type), total gastrectomy, and advanced pN stage are independent adverse prognostic factors.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.