ArticleMaterials today. Bio2026
A Janus polydopamine nanomotor hydrogel enables enhanced tumor penetration and potent synergistic photothermal-photodynamic therapy.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hydrogels are widely recognized as promising carriers for antitumor drug delivery owing to their tunable physicochemical properties. However, elevated interstitial fluid pressure and a dense extracellular matrix within tumors often restrict efficient drug penetration. Herein, we developed a nanomotor-based injectable hydrogel (CPPZ@R837) that integrates Janus-type polydopamine nanobowls (PDA NBs) functionalized with platinum nanoparticles (Pt NPs) as catalytic propellants and zinc phthalocyanine (ZnPc) as a photosensitizer to construct PPZ nanomotors (NMs). These PPZ NMs, together with the immunoadjuvant imiquimod (R837), were embedded into a chitosan (CTS)-based thermosensitive hydrogel through Michael addition and Schiff base reactions. Upon laser irradiation, the hydrogel underwent a sol-gel phase transition, enabling the controlled release of PPZ NMs and R837. The Pt NPs catalyzed the decomposition of tumor-overexpressed hydrogen peroxide (H
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