Curcumin alleviates depression-aggravated psoriasis by targeting MMP9-regulated apoptotic pathways.

Jiliang Lu, Chaojing Zhou, Ying Ma, Ningning Zhang, Ziyue Diao, Dandan Chen, Xin Tian, Zhiqiang Yin

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiliang LuDepartment of Dermatology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.

Chaojing ZhouDepartment of Dermatology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.

Ying MaState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Southeast University, Nanjing 210096, China.

Ningning ZhangThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China.

Ziyue DiaoDepartment of Dermatology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.

Dandan ChenDepartment of Dermatology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.

Xin TianDepartment of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Zhiqiang YinDepartment of Dermatology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression and psoriasis are highly comorbid, yet their shared molecular mechanisms remain poorly understood. Utilizing cross-sectional data from NHANES and Mendelian randomization (MR), a significant association and causal link between depression and psoriasis were established. A combined mouse model of chronic unpredictable mild stress (CUMS) and imiquimod-induced psoriasis confirmed that depressive state exacerbates psoriasis-like skin lesions. Integrated multi-omics analyses (including bulk and single-cell RNA sequencing, machine learning, and eQTL/pQTL-MR) identified apoptosis as a key shared pathway, with matrix metallopeptidase 9 (MMP9) as a central causal gene. Animal experiments confirmed MMP9 upregulation in both skin and brain tissues. Molecular docking predicted strong binding of curcumin to MMP9, and subsequent

Indexed as

Biological sciences

Identifiers

PMID42231964

DOI10.1016/j.isci.2026.115989

PMCPMC13224004

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.