ArticleDrug design, development and therapy2026
Oxycodone versus Sufentanil for Postoperative Analgesia and Early Recovery After Radical Gastrectomy: A Propensity Score-Matched Study.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Radical gastrectomy is associated with trauma and severe pain. We examined whether oxycodone could improve postoperative analgesia and early recovery compared with sufentanil in patients undergoing radical gastrectomy. Methods: Patients who underwent radical gastrectomy with patient-controlled intravenous analgesia (PCIA) based on sufentanil or oxycodone for postoperative pain management from January 2022 to December 2023 were included in this study. We used a 1:1 ratio propensity score matching (PSM) in our study to adjust for confounding factors and differences between groups. Patient demographics, surgical and anesthesia details, analgesic effects, and recovery profiles were recorded and analyzed. Results: After PSM, 224 patients were included in each group. Oxycodone treatment was associated with improved pain scores at rest and during movement at 2 h postoperatively ( Conclusion: Compared with sufentanil, oxycodone-based PCIA was associated with lower early postoperative pain scores, reduced immune suppression and fewer adverse reactions, and faster gastrointestinal function recovery.
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