ReviewDrug design, development and therapy2026
Calcium Signaling Dysregulation as a Convergent Mechanism in Anesthetic-Induced Developmental Neurotoxicity.
Review in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Exposure to general anesthetics during critical periods of brain development is associated with altered neurogenesis and long-term neurobehavioral abnormalities in preclinical models, although clinical evidence remains inconclusive. Dysregulation of intracellular calcium signaling has emerged as an important convergent mechanism underlying anesthetic-induced developmental neurotoxicity (AIDN). Calcium serves as a pivotal second messenger regulating neural stem cell (NSC) quiescence, proliferation, fate specification, neuronal maturation; its precise spatiotemporal dynamics are essential for normal brain development. Common anesthetics including propofol, ketamine, sevoflurane, isoflurane, and midazolam act primarily as GABA
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