ArticleSurgical neurology international2026
Dural-based melanoma metastasis mimicking a posterior fossa meningioma: A case report and review of the literature.
Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Intracranial metastases are a common complication in patients with systemic cancer; however, dural-based metastatic tumors represent a rare subset. To the best of our knowledge, only a limited number of cases of melanoma brain metastases mimicking meningiomas have been reported in the literature. We describe a case of a posterior fossa dural-based melanoma metastasis and review relevant literature from the past 10 years. Case Description: A 41-year-old woman with a history of the left eye enucleation due to intraocular melanoma, without regular medical follow-up, presented with a 4-month history of localized occipital headache, followed by progressive dizziness and lower limb incoordination. Magnetic resonance imaging revealed a dural-based posterior fossa lesion at the foramen magnum with radiological features highly suggestive of a meningioma. The patient underwent complete surgical resection, and histopathological analysis confirmed metastatic melanoma. Adjuvant treatment consisted of radiotherapy and immunotherapy with ipilimumab. Conclusion: Dural-based melanoma metastases may closely mimic meningiomas both clinically and radiologically, posing a significant diagnostic challenge. Surgical management is indicated in symptomatic cases, particularly those associated with mass effect or focal neurological deficits. Adjuvant radiotherapy and immunotherapy remain important components of treatment.
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