SynthesisFrontiers in oncology2026
Association between infertility and thyroid cancer risk: a systematic review and meta-analysis.
Synthesis in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Epidemiologic evidence on the association between infertility and thyroid cancer risk remains inconsistent. We conducted a systematic review and meta-analysis to synthesize available observational evidence and quantify this association. Methods: We systematically searched PubMed, Web of Science, and Scopus from inception to February 10, 2026, to identify observational studies evaluating the association between infertility and thyroid cancer risk. Eligible cohort and case-control studies reporting relative effect estimates with 95% confidence intervals (CIs) were included. Summary risk estimates were pooled using random-effects models. Between-study heterogeneity was assessed using the Results: Nine studies met the inclusion criteria, including seven cohort studies and two case-control studies, comprising a total of 4,563,090 participants. In the pooled analysis, infertility was associated with a significantly higher risk of thyroid cancer (relative risk [RR], 1.37; 95% CI, 1.15-1.63), with substantial heterogeneity across studies ( Conclusions: This study suggests that infertility is associated with an increased risk of thyroid cancer. Although substantial heterogeneity was observed, the association remained consistent across multiple sensitivity analyses. However, further well-designed research is needed to verify and clarify this association and its underlying mechanisms.
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