Evidence mapPaperPMID 42232566Full record

ReviewERJ open research2026

Exploring the therapeutic potential of GLP-1 receptor agonists in pulmonary arterial hypertension.

Benoit Aguado, Thomas Lacoste-Palasset, Grégoire Ruffenach, Fabrice Bauer, Laurent Savale, Marc Humbert, David Montani, Fabrice Antigny

Abstract readReview
In one paragraph

Review in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benoit AguadoUniversité Paris-Saclay, INSERM UMR_S 1358, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Le Plessis Robinson, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0009-0005-6895-194X
Thomas Lacoste-PalassetUniversité Paris-Saclay, INSERM UMR_S 1358, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Le Plessis Robinson, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0003-3543-6675
Grégoire RuffenachUniversité Paris-Saclay, INSERM UMR_S 1358, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Le Plessis Robinson, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0001-6419-4332
Fabrice BauerUniversité Paris-Saclay, INSERM UMR_S 1358, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Le Plessis Robinson, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0002-9221-9688
Laurent SavaleUniversité Paris-Saclay, INSERM UMR_S 1358, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Le Plessis Robinson, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0002-6862-8975
Marc HumbertUniversité Paris-Saclay, INSERM UMR_S 1358, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Le Plessis Robinson, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0003-0703-2892
David MontaniUniversité Paris-Saclay, INSERM UMR_S 1358, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Le Plessis Robinson, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0002-9358-6922
Fabrice AntignyUniversité Paris-Saclay, INSERM UMR_S 1358, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Le Plessis Robinson, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0002-9515-6571

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary hypertension (PH) is a progressive and multifactorial disease marked by elevated pulmonary arterial pressure and right ventricular (RV) dysfunction. Among its subtypes, pulmonary arterial hypertension (PAH) is characterised by profound vascular remodelling, inflammation and fibrosis. Despite therapeutic advances targeting the endothelin, nitric oxide, prostacyclin, and, more recently, the activin signalling pathway

Identifiers

PMID42232566
PMCPMC13224206

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.