ReviewRSC chemical biology2026
Cooperative membrane association as a mechanistic origin of synergistic antimicrobial peptide activity.
Review in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Membrane-Targeted Consequences of Acetaminophen Toxicity and Off-Target Effects of Antimicrobial Peptides on Host Cell Membranes.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides (AMPs) are central components of the innate immunity system that can be found in almost all living organisms. They are promising alternatives to conventional antibiotics due to their broad-spectrum activity and reduced susceptibility to resistance. Experimental studies have shown that combinations of AMPs can act synergistically, achieving enhanced antibacterial efficacy at lower total concentrations in combination than individually. However, despite its prevalence, AMP synergy has until recently been lacking a unifying mechanistic and predictive framework. In this review, we combine the latest theoretical, computational, and experimental advances to present a novel quantitative framework that views AMP synergy as a consequence of cooperative membrane association. Chemical-kinetic models of AMPs association to bacterial membranes show that favorable intermolecular interactions between different AMP species accelerate their binding, enhancing antibacterial activity. Within this framework, an effective interaction parameter, Δ
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.