Evidence map›Paper›PMID 42232749›Full record

ArticleBioactive materials2026

Astaxanthin-metformin conjugate nanomicelles-loaded hydrogel reprograms macrophage metabolism

Xin-Nan Teng, Hui Wang, Yue Zhu, Shu-Chang Wang, Run-Long Pan, Chen Du, Run-Fang Song, Shuai-Shuai Zhang, Jun-Rong Li, Song-Bai Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xin-Nan TengState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Hui WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Yue ZhuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Shu-Chang WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Run-Long PanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Chen DuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Run-Fang SongState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Shuai-Shuai ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Jun-Rong LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Song-Bai ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Feng XuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Qian ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Min ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wounds struggle to heal because of ROS-mediated immune dysfunction, in which the mitochondrial metabolic reprogramming of macrophages is critical for inflammation resolution and tissue repair. Here, we innovatively combine the antioxidant astaxanthin (Ast) and the metabolic activator metformin (Met)

Indexed as

Astaxanthin-metformin conjugateDiabetic wound healingHydrogelMacrophage reprogrammingMitochondria

Identifiers

PMID42232749
PMCPMC13224144

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.