Evidence map›Paper›PMID 42233670›Full record

ArticleMicrobiology spectrum2026

The novel antifungal agent NPD2560 perturbs the Rho1-centered signaling network to induce a cell wall integrity response.

Wei Liu, Hiroki Sekiguchi, Sheena C Li, Luis Alberto Vega Isuhuaylas, Daisuke Yamanaka, Kaori Itto-Nakama, Yoichi Noda, Charles Boone, Yoko Yashiroda, Yoshikazu Ohya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei LiuDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Hiroki SekiguchiDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Sheena C LiRIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Luis Alberto Vega IsuhuaylasTerrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.
Daisuke YamanakaLaboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Kaori Itto-NakamaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Yoichi NodaGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Charles BooneRIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Yoko YashirodaRIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Yoshikazu OhyaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.ORCID 0000-0003-0837-1239

Funding

Japan Society for the Promotion of Science 22K06522Japan Society for the Promotion of Science 23H04882Japan Society for the Promotion of Science 23K23483Japan Society for the Promotion of Science 23K27411Japan Society for the Promotion of Science 25K01916Japan Society for the Promotion of Science JPJS00420240017
6 · The paper itself

Abstract

Fungal pathogens pose an increasing threat to human health. The limited diversity of antifungal drug classes and the rapid emergence of resistance highlight the urgent need for the identification and development of agents with novel mechanisms of action. Here, we identified NPD2560, a coumarin-derived compound, as an antifungal agent that exhibits fungicidal activity against

Indexed as

Antifungal AgentsCandidaCell WallCoumarinsrho GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsSignal Transductionbeta-GlucansDrug Resistance, FungalEchinocandinsGene Expression Regulation, FungalGlucosyltransferasesMembrane ProteinsMicrobial Sensitivity TestsSaccharomyces cerevisiaeAntifungal Agentsbeta-GlucansCoumarinsEchinocandinsFKS1 protein, S cerevisiaeGlucosyltransferasesMembrane ProteinsRHO1 protein, S cerevisiaerho GTP-Binding ProteinsSaccharomyces cerevisiae Proteinsantifungal agentsCandida kruseicell wall integrity pathwayFks1Rho1β-(1,6)-glucan

Identifiers

PMID42233670
PMCPMC13340020

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.