Evidence map›Paper›PMID 42233693›Full record

ArticleCartilage2026

Hyperbaric Oxygen Therapy Improves Subchondral Perfusion and Cartilage Integrity in Established Osteoarthritis: A Pharmacokinetic DCE-MRI and T2* Quantification Study.

Guo-Shu Huang, Shih-Wei Chiang, Chiao-Chi Chen, Yi-Jen Peng, Yu-Juei Hsu, Kun-Lun Huang, Yu-Ching Chou, Ming-Huang Lin, Ying-Chun Liu, Chao-Ying Wang

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In one paragraph

Article in Cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guo-Shu HuangDepartment of Radiology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
Shih-Wei ChiangDepartment of Radiology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.ORCID 0000-0002-9672-1077
Chiao-Chi ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yi-Jen PengDepartment of Pathology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
Yu-Juei HsuDivision of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
Kun-Lun HuangGraduate Institute of Medical Sciences, College of Medicine, National Defense Medical University, Taipei, Taiwan.
Yu-Ching ChouInstitue of Long-Term Care, Mackay Medical University, New Taipei, Taiwan.
Ming-Huang LinInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Ying-Chun LiuGraduate Institute of Biology and Anatomy, College of Medicine, National Defense Medical University, Taipei, Taiwan.
Chao-Ying WangGraduate Institute of Biology and Anatomy, College of Medicine, National Defense Medical University, Taipei, Taiwan.ORCID 0000-0002-5504-5463

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveThis study investigated whether hyperbaric oxygen (HBO) therapy, initiated after disease establishment, exerts disease-modifying effects in a rat model of anterior cruciate ligament transection (ACLT)-induced post-traumatic osteoarthritis (PTOA).DesignThirty-six Sprague-Dawley rats underwent ACLT surgery. HBO therapy commenced at Week 11 (established OA phase) and continued for 6 weeks. Outcomes were assessed using Von Frey testing, multimodal 7T MRI (T2* quantification and pharmacokinetic DCE-MRI), and histopathology.ResultsBy Week 10, ACLT induced significant mechanical allodynia, T2* prolongation, and SCB perfusion abnormalities (

Indexed as

angiogenesisDCE-MRIhyperbaric oxygen therapypost-traumatic osteoarthritissubchondral bone microcirculationT2* quantification

Identifiers

PMID42233693
PMCPMC13233603

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.