ArticleRheumatology international2026
Characterizing symptom burden in knee osteoarthritis: the predominant role of Kellgren-Lawrence grade 4 in functional decline and pain severity.
Article in Rheumatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Acupoint Selection Patterns and Potential Mechanisms of Acupuncture in Knee Osteoarthritis: A Combined Data Mining and Network Pharmacology Study.Journal of pain research · 2026Article
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Abstract
Knee osteoarthritis (KOA) causes pain, functional impairments, and sleep disturbances. This study aimed to assess differences in pain pattern, insomnia, function, and muscle strength across Kellgren-Lawrence grades in patients with KOA. In this cross-sectional study, 82 patients (65.8 ± 7.8 years) were categorized into Kellgren-Lawrence Grade 2 (n = 20), Grade 3 (n = 20), and Grade 4 (n = 42). Pain (VAS, ICOAP), insomnia (ISI), knee function (KOS-ADLS), functional performance (Timed-Up and Go [TUG], Five Times Sit-to-Stand [FTSST]), and isometric muscle strength were evaluated. Comparisons were performed using ANCOVA, adjusting for age and BMI. Groups differed significantly in age and BMI (p < 0.001 and p = 0.024), with higher values in Grade 4. Significant between-group differences were observed in VAS (p = 0.006), ICOAP-constant pain (p = 0.037), ICOAP-total pain (p = 0.035), TUG (p = 0.021), KOS-ADLS (p = 0.015), and quadriceps strength of the affected knee (p < 0.001) and hip adductor strength (p = 0.046). No significant differences were found for ICOAP-intermittent pain, ISI, or non-affected knee quadriceps strength (p > 0.05). Pairwise comparisons showed that Grade 4 patients had significantly worse outcomes than Grade 2 in VAS (p = 0.013), ICOAP-constant pain (p = 0.041), and total pain (p = 0.047), and TUG (p = 0.025), as well as reduced quadriceps strength of both affected (p < 0.001) and non-affected (p = 0.019) knees. Differences between Grades 2 and 3 were limited to VAS (p = 0.026), while Grades 3 and 4 differed only in KOS-ADLS (p = 0.022). Higher Kellgren-Lawrence grades were associated with greater pain, poorer function, and reduced quadriceps strength, particularly in Grade 4, emphasizing the clinical relevance of radiographic grading in characterizing symptom burden in KOA.
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