Evidence map›Paper›PMID 42234530›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.

Maria L White, Julien Mortier, Lova Granqvist, Deike J Omnus, Max Louski, Nick Crang, Berent Aldikacti, Valérie Migeot, Peter Chien, Marc Hennequart and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria L WhiteDepartment of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm University, Stockholm 10691, Sweden.ORCID 0000-0003-4209-0887
Julien MortierDepartment of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm University, Stockholm 10691, Sweden.
Lova GranqvistDepartment of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm University, Stockholm 10691, Sweden.ORCID 0009-0001-7369-7692
Deike J OmnusDepartment of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm University, Stockholm 10691, Sweden.ORCID 0000-0002-4091-4291
Max LouskiDepartment of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm University, Stockholm 10691, Sweden.ORCID 0000-0003-3771-1976
Nick CrangSchool of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm 10044, Sweden.ORCID 0000-0002-7569-6597
Berent AldikactiBiochemistry and Molecular Biology Department, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0002-8916-8007
Valérie MigeotMolecular Physiology Research Unit, Namur Research Institute for Life Science, University of Namur, Namur 5000, Belgium.
Peter ChienBiochemistry and Molecular Biology Department, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0001-6733-1478
Marc HennequartMolecular Physiology Research Unit, Namur Research Institute for Life Science, University of Namur, Namur 5000, Belgium.ORCID 0000-0003-4360-6830
Régis HallezBacterial Cell cycle and Development, Biology of Microorganisms Research Unit, Namur Research Institute for Life Science, University of Namur, Namur 5000, Belgium.ORCID 0000-0003-1175-8565
Kristina JonasDepartment of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm University, Stockholm 10691, Sweden.ORCID 0000-0002-1469-4424

Funding

Regulated Proteolysisin Bacteria Development and Stress ResponseR35GM130320 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Peter Chien · 2019 to 2026
$3.4M
Fonds De La Recherche Scientifique - FNRS (FNRS) CDR J.0096.22HHS | National Institutes of Health (NIH) R35GM130320Science for Life Laboratory (SciLifeLab) N/AVetenskapsrådet (VR) 2020-03545Vetenskapsrådet (VR) 2024-04942Walloon excellence in life sciences and biotechnology (WELBIO) WELBIO-CR-2019S-05
6 · The paper itself

Abstract

Inorganic polyphosphate (polyP) is a ubiquitous molecule found across all domains of life. Although implicated in diverse cellular processes, including phosphate storage, stress responses, and pathogenicity, loss of polyP synthesis typically causes only mild growth defects. Here, we demonstrate an essential physiological role for polyP synthesis during recovery from phosphate starvation, when cells transition from phosphate-limited to phosphate-replete conditions. Using a comprehensive transposon sequencing approach in

Indexed as

Adenosine TriphosphatePhosphatesPolyphosphatesBacterial ProteinsCaulobacter crescentusEnvironmental MicrobiologyHomeostasisNutrientsPhosphotransferases (Phosphate Group Acceptor)Adenosine TriphosphateBacterial ProteinsPhosphatesPhosphotransferases (Phosphate Group Acceptor)polyphosphate kinasePolyphosphatesCaulobacter crescentusnutrient adaptationPolyPPpk1Pst system

Identifiers

PMID42234530
PMCPMC13250506

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.