In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Marcello Magri AmaralDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-9962-5646 Abigail MattDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Kaelyn H SchlossDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-4323-7019 Fei WangDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-0890-4595 Elena GrachevaDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Yuxuan WangDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Hongwu LiangDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Jimin DingDepartment of Statistics & Data Science, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0009-0007-5520-4069 Attila KovacsCenter for Cardiovascular Research, Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Carla WeinheimerCenter for Cardiovascular Research, Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-7922-7512 Abhinav DiwanDepartment of Cell Biology and Physiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-7554-4772 Jianmin CuiDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-9198-6332 Stacey L RentschlerDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-1744-1238 Jeanne NerbonneCenter for Cardiovascular Research, Department of Medicine, Cardiovascular Division, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-8334-8499 Christian W ZemlinDivision of Cardiothoracic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-5834-5544 Adam Q BauerDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-8364-3209 Chao ZhouDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-8679-3413 Funding
High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heartR01HL156265 · NHLBI · WASHINGTON UNIVERSITY · PI Chao Zhou · 2022 to 2024
$1.5MNHLBI NIH HHS R01 HL156265NIBIB NIH HHS R01 EB025209NIBIB NIH HHS R21 EB032684
6 · The paper itselfAbstract
Mouse models are valuable for studying the systemic effects of arrhythmia, but traditional methods of heart pacing are invasive and technically complex. Cardiac optogenetics enables precise control of cardiac activity using light-sensitive ion channels and has been used for tachypacing, resynchronization, and defibrillation in animal models. Recent advances in opsins with red-shifted activation spectra and optimized light delivery strategies have enhanced noninvasive pacing approaches, particularly in mammalian models. Here, we use an area illumination approach for light stimulation through the intact chest to perform in vivo, noninvasive optogenetic tachypacing in transgenic mice expressing ReaChR with low irradiance (<1 mW/mm
Indexed as
Arrhythmias, CardiacHemodynamicsOptogeneticsAnimalsDisease Models, AnimalMiceMice, Transgenic
Identifiers
PMID42234736
PMCPMC13232562
What Socratic holds
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LicenceCC BY
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