Evidence mapPaperPMID 42234741Full record

ArticleScience advances2026

Identification of a shared antigen linking CD4

Masaru Takeshita, Jun Inamo, Seiki Wakui, Ryosuke Nagashima, Takahiro Nishino, Kazuyuki Tsunoda, Satoshi Usuda, Hajime Inokuchi, Kazuyoshi Ishigaki, Takashi Sasaki and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Masaru TakeshitaDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-3281-6595
Jun InamoDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-9927-7936
Seiki WakuiJSR-Keio University Medical and Chemical Innovation Center (JKiC), JSR Corp., 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0009-0008-8727-6750
Ryosuke NagashimaJSR-Keio University Medical and Chemical Innovation Center (JKiC), JSR Corp., 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Takahiro NishinoDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0002-6441-7572
Kazuyuki TsunodaDepartment of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-3214-6288
Satoshi UsudaDepartment of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
Hajime InokuchiDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0009-0005-3514-3102
Kazuyoshi IshigakiDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0003-2881-0657
Takashi SasakiCenter for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-6275-046X
Yuki KagoyaDivision of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-6216-6730
Katsuya SuzukiDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Yuko KanekoDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0003-2646-5765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sjögren's disease (SjD) is an autoimmune disorder characterized by lymphocytic infiltration of exocrine glands. Although B cells producing anti-Ro60 autoantibodies are frequently found in salivary gland lesions, the antigen specificity of CD4

Indexed as

AutoantigensB-LymphocytesCD4-Positive T-LymphocytesSjogren's SyndromeAutoantibodiesHumansLymphocyte ActivationReceptors, Antigen, T-CellRibonucleoproteinsRNA, Small CytoplasmicSalivary GlandsSS-A AntigenAutoantibodiesAutoantigensReceptors, Antigen, T-CellRibonucleoproteinsRNA, Small CytoplasmicRO60 protein, humanSS-A Antigen

Identifiers

PMID42234741
PMCPMC13232566

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.