Evidence map›Paper›PMID 42234776›Full record

ArticleScience translational medicine2026

Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction.

Caiwei Guo, Kuchuan Chen, Sarat Vatsavayai, Tetsuya Akiyama, Chang Liu, Yi Zeng, Odilia Sianto, Edith Yang, Juliane Bombosch, Rasheen Powell and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. TDP-43: [GU]-ardian of the transcriptome.Molecular neurodegeneration · 2026
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Caiwei GuoDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-9975-9732
Kuchuan ChenF.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8206-482X
Sarat VatsavayaiMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-1889-0019
Tetsuya AkiyamaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-8076-1242
Chang LiuDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-5219-1089
Yi ZengDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-8306-8323
Odilia SiantoDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Edith YangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Juliane BomboschDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Rasheen PowellF.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-4423-6413
Shannon ZhenF.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0007-7446-3074
Shila MekhoubadTrace Neuroscience, South San Francisco, CA 94080, USA.
Ryan D MorrieTrace Neuroscience, South San Francisco, CA 94080, USA.
Georgiana MillerTrace Neuroscience, South San Francisco, CA 94080, USA.ORCID 0000-0002-9742-0049
Dragana IlicLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin 13125, Germany.ORCID 0000-0002-3725-7964
Moritz BollLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin 13125, Germany.ORCID 0009-0006-2647-5348
Euan ParnellDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Peter PenzesDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-9280-7850
Noa LipsteinLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin 13125, Germany.ORCID 0000-0002-0755-5899
Eric M GreenTrace Neuroscience, South San Francisco, CA 94080, USA.ORCID 0000-0001-7874-9482
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-2959-129X
William W SeeleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-1410-2027
Aaron D GitlerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-8603-1526

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TAR DNA binding protein 43 (TDP-43) pathology is a defining pathological hallmark of multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A major feature of TDP-43 pathology is its nuclear depletion, leading to the aberrant inclusion of cryptic exons during RNA splicing.

Indexed as

Cell MembraneDNA-Binding ProteinsNeuronsRNA SplicingSynapsesAmyotrophic Lateral SclerosisAnimalsFrontotemporal DementiaHumansSynaptic TransmissionDNA-Binding ProteinsTARDBP protein, human

Identifiers

PMID42234776

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.