Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling.

Ying Zhang, Xiaoxian Zhao, Xinyi Han, Xuemin Shen, Runyu Huang, Wei Liu, Lan Wu

Abstract read

In one paragraph

Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Ying ZhangDepartment of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, China.

Xiaoxian ZhaoDepartment of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, China.

Xinyi HanDepartment of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, China.

Xuemin ShenDepartment of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, China.

Runyu HuangDepartment of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, China.

Wei LiuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, China. Electronic address: liuweb@hotmail.com.

Lan WuDepartment of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, China. Electronic address: teana_wu@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salvianolic acid B (SalB), a major component of Danshen, the ancient Chinese herb Salvia miltiorrhiza Bunge, has demonstrated inhibitory effects against various solid tumours. Our previous study explored a SalB-loaded nanocarrier as a photosensitizing formulation for photodynamic therapy (PDT) in vitro in oral leucoplakia (OLK) and oral cancer cells. This study aims to explore the underlying mechanisms and in vivo effects. In this study, different concentrations of SalB and 5-aminolevulinic acid (ALA) were incorporated into liposomes to synthesize the nano-photosensitizer (nano-SalB-ALA). Reactive oxygen species (ROS) levels in Cal27 and Leuk1 cells were evaluated by DCFH-DA staining, and the intracellular distribution of fluorescently labelled liposomes was visualized by confocal laser scanning microscopy (CLSM). Western blot was used to analyse the expression of PI3K/AKT/mTOR signalling proteins. In addition, a 4NQO-induced OLK mouse model was used to evaluate in vivo effects. Based on the most obvious intracellular ROS fluorescence signals and the greatest reduction in PI3K/AKT/mTOR signalling pathway expression observed in the nano-SalB

Indexed as

Aminolevulinic AcidBenzofuransPhotochemotherapyPhotosensitizing AgentsProto-Oncogene Proteins c-aktReactive Oxygen SpeciesTOR Serine-Threonine KinasesAnimalsBlotting, WesternDepsidesHumansLiposomesMiceMicroscopy, ConfocalSignal TransductionAminolevulinic AcidBenzofuransDepsidesLiposomesPhotosensitizing AgentsProto-Oncogene Proteins c-aktReactive Oxygen Speciessalvianolic acid BTOR Serine-Threonine KinasesOral leucoplakiaPhotodynamic therapyPI3K/AKT/mTOR signalling pathwayReactive oxygen speciesSalvianolic acid B

Identifiers

PMID42235408

DOI10.1016/j.identj.2026.109634

PMCPMC13265678

What Socratic holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.