Evidence map›Paper›PMID 42236715›Full record

ArticleNature communications2026

Elp3 uses a conserved molecular tunnel to transport acetate between distant active sites and catalyze tRNA wobble base modification.

Evan P Geissler, Youmna Moawad, Paige N Roehling, Cassidy Driscoll, Katherine Martin, Papa Nii Asare-Okai, Jeffrey S Mugridge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evan P Geissler *Department of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA.
Youmna Moawad *Department of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA.ORCID 0009-0009-4872-3017
Paige N RoehlingDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA.ORCID 0000-0002-7893-8483
Cassidy DriscollDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA.
Katherine MartinDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA.
Papa Nii Asare-OkaiDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA.
Jeffrey S MugridgeDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA. mugridge@udel.edu.ORCID 0000-0002-1553-3008

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Selectivity and regulation of mRNA demethylation by iron-dependent dioxygenasesR35GM143000 · NIGMS · UNIVERSITY OF DELAWARE · PI MUGRIDGE, JEFFREY SCOTT · 2021 to 2025
$2.1M
National Science Foundation (NSF) 2339759NIGMS NIH HHS P20 GM104316NIGMS NIH HHS R35 GM143000
6 · The paper itself

Abstract

The radical SAM enzyme Elp3 and eukaryotic Elongator complex catalyze formation of a key intermediate transfer RNA (tRNA) modification, 5-carboxymethyluridine (cm

Indexed as

AcetatesHistone AcetyltransferasesRNA, TransferAnticodonCatalytic DomainHumansModels, MolecularAcetatesAnticodonHistone AcetyltransferasesRNA, Transfer

Identifiers

PMID42236715
PMCPMC13315578

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.