Evidence map›Paper›PMID 42236779›Full record

ArticleScientific reports2026

Effects of environmental enrichment on lymph node mitochondrial-redox status and immune response in adult male C57BL/6 mice.

Matheus Santos de Sousa Fernandes, Alexandre Kanashiro, Débora Eduarda da Silva Fidélis, Tiago Lacerda Ramos, Burak Yagin, Fatma Hilal Yagin, Vanessa Lima de Souza, Claudia Jacques Lagranha, Monira I Aldhahi, Fabrício Oliveira Souto

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matheus Santos de Sousa FernandesKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil. matheus.sfernandes@ufpe.br.
Alexandre KanashiroDepartment of Pharmacology, Ribeirao Preto Medical School of the University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Débora Eduarda da Silva FidélisKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Tiago Lacerda RamosKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Burak YaginDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu University, 44280, Malatya, Turkey.
Fatma Hilal YaginDepartment of Biostatistics, Faculty of Medicine, Malatya Turgut University, 44210, Malatya, Turkey.
Vanessa Lima de SouzaLaboratory of Biochemistry and Molecular Biology of Physical Exercise, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil.
Claudia Jacques LagranhaLaboratory of Biochemistry and Molecular Biology of Physical Exercise, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil.
Monira I AldhahiDepartment of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0002-5255-4860
Fabrício Oliveira SoutoKeizo Asami Institute, Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Funding

Princess Nourah bint Abdulrahman University Researchers Supporting Project PNURSP2026R286
6 · The paper itself

Abstract

Environmental enrichment (EE), an experimental paradigm promoting cognitive, sensory, social, and motor stimulation, has been associated with neuroprotective effects. Although EE modulates immune function, its influence on the basal redox and metabolic environment of lymph nodes remains unclear. This study investigated whether EE induces physiological immunometabolic and redox adaptations in lymph nodes under non-pathological conditions. Adult male C57BL/6 mice were housed for six weeks in either a standard environment (SE) or EE, followed by evaluation of mitochondrial markers, redox balance, antioxidant defenses in axillary lymph nodes, and systemic basal cytokine profiles. EE did not modify citrate synthase activity, indicating preserved mitochondrial content. Both NAD

Indexed as

EnvironmentLymph NodesMitochondriaAnimalsAntioxidantsCytokinesGlutathioneLipid PeroxidationMaleMiceMice, Inbred C57BLOxidation-ReductionOxidative StressAntioxidantsCytokinesGlutathioneBlood cytokinesEnvironmental enrichmentInflammationLymph nodeRedox status

Identifiers

PMID42236779
PMCPMC13470239

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.