Evidence map›Paper›PMID 42236853›Full record

ArticleScientific reports2026

Endothelial SP1 lactylation promotes bronchopulmonary dysplasia via regulation of Cdkn1a expression.

Ziming Zhang, Qiqi Li, Xinmin Ju, Lingchen Li, Tian Xie, Lu Zu, Qianyun Cao, Mengting Hu, Yun Ling, Lingling Yan and 8 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ziming Zhang *Neonatal Intensive Care Unit, Children's Hospital, School of Medicine, Zhejiang University, National Clinical Research Center for Child Health, Hangzhou, China.
Qiqi Li *Zhejiang Key Laboratory of Neonatal Diseases, Hangzhou, China.
Xinmin Ju *Zhejiang Key Laboratory of Neonatal Diseases, Hangzhou, China.
Lingchen LiZhejiang Key Laboratory of Neonatal Diseases, Hangzhou, China.
Tian XieNeonatal Intensive Care Unit, Children's Hospital, School of Medicine, Zhejiang University, National Clinical Research Center for Child Health, Hangzhou, China.
Lu ZuZhejiang Key Laboratory of Neonatal Diseases, Hangzhou, China.
Qianyun CaoZhejiang Key Laboratory of Neonatal Diseases, Hangzhou, China.
Mengting HuDepartment of Pulmonology, Children's Hospital, School of Medicine, Zhejiang University, National Clinical Research Center for Child Health, Hangzhou, China.
Yun LingAcademy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Lingling YanDepartment of Pediatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Tieshuai LiuDepartment of Anesthesiology, Sir Run Run Shaw Hospital School of Medicine, Zhejiang University, Hangzhou, China.
Jiajing GeNeonatal Intensive Care Unit, Children's Hospital, School of Medicine, Zhejiang University, National Clinical Research Center for Child Health, Hangzhou, China.
Xiaolu MaDepartment of Neonatology, Women's Hospital School of Medicine, Key Laboratory& Women's Hospital, Zhejiang University, Hangzhou, China.
Zheng ChenNeonatal Intensive Care Unit, Children's Hospital, School of Medicine, Zhejiang University, National Clinical Research Center for Child Health, Hangzhou, China.
Jiajun ZhuDepartment of Neonatology, Women's Hospital School of Medicine, Key Laboratory& Women's Hospital, Zhejiang University, Hangzhou, China.
Jia HeTeaching Experimental Center of Public Health, Zhejiang University, Hangzhou, China. hejia1005@zju.edu.cn.
Wei ShiNeonatal Intensive Care Unit, Children's Hospital, School of Medicine, Zhejiang University, National Clinical Research Center for Child Health, Hangzhou, China. 0021084@zju.edu.cn.
Lizhong DuZhejiang Key Laboratory of Neonatal Diseases, Hangzhou, China. dulizhong@zju.edu.cn.

Funding

National Natural Science Foundation of China 82201890National Natural Science Foundation of China 82241017National Natural Science Foundation of China No.32200748Wu Jieping Medical Foundation 320.6750.2025-9-25Zhejiang Provincial Natural Science Foundation No.LMS26H040003
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is a major complication of prematurity, and endothelial dysfunction contributes to its pathogenesis. Although lactate metabolism is dysregulated in BPD, whether lactate-derived lysine lactylation contributes to endothelial dysfunction remains unknown. This study investigated the role of lactylation in endothelial injury and the involvement of SP1-Cdkn1a axis in BPD. We found that lactate levels and global lactylation levels were increased in both in vitro and in vivo models of BPD, accompanied by impaired endothelial proliferation, migration and angiogenic capacity. Integrated bioinformatic analysis identified Cdkn1a as a glycolysis-associated hub gene in BPD, and its upregulation in pulmonary vascular endothelial cells (PVECs) was confirmed experimentally. Subsequent Cdkn1a knockdown alleviated hyperoxia-induced endothelial dysfunction. In addition, inhibition of glycolysis reduced lactylation level in PVECs, suppressed Cdkn1a expression, and partially improved pulmonary microvascular injury. To explore the upstream mechanism, lactylome profiling identified SP1, a known transcription factor of Cdkn1a, as a lactylated candidate. Increased SP1 lactylation and enhanced binding at the Cdkn1a promoter were verified in PVECs from BPD mice. K640R mutation attenuated SP1-dependent Cdkn1a promoter activation. Overall, this study reveals the involvement of endothelial lactylation in pathogenesis of BPD and implicates the SP1-Cdkn1a axis as a potential therapeutic target.

Indexed as

Bronchopulmonary DysplasiaCyclin-Dependent Kinase Inhibitor p21Endothelial CellsLactic AcidSp1 Transcription FactorAnimalsCell MovementCell ProliferationGene Expression RegulationGlycolysisHumansMaleMicePromoter Regions, GeneticCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Lactic AcidSP1 protein, humanSp1 Transcription FactorBronchopulmonary dysplasiaCdkn1aEndothelial dysfunctionHyperoxiaLactylationSP1

Identifiers

PMID42236853

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.