ArticleNature neuroscience2026
A brainstem pathway underlying vagal modulation of somatic pain and affective states.
Yuan Tang, Ruixinzhu Shao, Liuxinyu Luo, Liqiang Liao, Xiaoyu Wang, Hangfei Zhu, Xiong Xiao, Hanfei Deng
Abstract read
In one paragraphArticle in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Yuan Tang *State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Ruixinzhu Shao *State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Liuxinyu LuoState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Liqiang LiaoState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Xiaoyu WangState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Hangfei ZhuState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Xiong XiaoInstitute of Neuroscience, State Key Laboratory of Brain Science on Cognition and Brain-inspired Intelligence, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. xiao@ion.ac.cn.ORCID http://orcid.org/0000-0002-2407-7649 Hanfei DengState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China. hanfeideng@fudan.edu.cn.ORCID http://orcid.org/0009-0003-7070-461X Funding
National Natural Science Foundation of China (National Science Foundation of China) 32271065National Natural Science Foundation of China (National Science Foundation of China) 32371060
6 · The paper itselfAbstract
Vagus nerve stimulation (VNS) alleviates pain, yet the underlying neural mechanisms remain elusive. Furthermore, the caudal nucleus of the solitary tract (cNTS) receives vagal and somatic inputs, but how it transforms pain signals into behavior and how VNS modulates this processing remain unclear. Here we identified a population of cNTS neurons projecting to the periaqueductal gray (PAG) (cNTS
Indexed as
AffectBrain StemNociceptive PainPeriaqueductal GraySolitary NucleusVagus NerveAnimalsMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsNociceptionOptogenetics
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