Trial reportBMC public health2026
Implementation of an Internet-based psychological intervention for the treatment of mild depression in primary care: a hybrid effectiveness-implementation approach.
Trial report in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05294614 (Implementation of a Psychological Online Intervention for Low to Moderate Depression in Primary Health Care), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementation of a Psychological Online Intervention for Low to Moderate Depression in Primary Health Care: a Study Protocol
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundDepression is a significant global challenge. Particularly in Spain, depression in Primary Care (PC) settings is prevalent and inadequately addressed. Online interventions, such as "Smiling is Fun", an online Cognitive Behavioral program, offer promising solutions given its scalability and accessibility. However, successful implementation in real-world settings requires identifying and addressing contextual barriers. This study aims to implement "Smiling is Fun" while assessing its effectiveness and the determinants influencing its implementation.
methodsThe study employed a Hybrid Effectiveness-Implementation Type II approach using a Stepped-Wedge Cluster Randomized-Controlled Trial methodology. Six sites were randomized into three clusters, each undergoing treatment conditions for 16 weeks. Patients were recruited by health professionals in PC settings.
resultsThe intervention effectively reduced depressive symptoms and improved positive affect. Participants generally had a positive attitude towards internet interventions, although there was a an increase in concerns about lack of direct professional contact.. Overall satisfaction among participants who completed the intervention was moderately high, but problems with treatment adherence were observed. Professionals demonstrated a willingness to adopt the program, with generally high readiness to implement the intervention. Nevertheless, some important barriers, such as high levels of stress, insufficient learning time, and personnel changes were highlighted.
conclusions"Smiling is Fun" demostrated to be effective in addressing mental health states and depressive symptomatology, with positive perceptions from both professionals and patients. However, barriers need to be addressed, particularly in fostering inclusion in the PC workflow system and promoting patient adherence. Despite limitations, the study underscores the potential of online interventions to improve mental healthcare accessibility.
trial registrationhttps://clinicaltrials.gov/study/NCT05294614 (23/03/2022, retrospectively registered).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.