Evidence map›Paper›PMID 42237295›Full record

ArticleBMC medicine2026

CIITA/PRMT5 promote CD4

Yuwu Chen, Xing Luo, Biyi Xu, Xinxin Zhu, Junke Mou, Mengyang Wang, Qishuo Gu, Yuehong Wang, Xiaoxuan Bai, Shan Zhang and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yuwu Chen *Department of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Xing Luo *Department of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Biyi Xu *Department of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Xinxin Zhu *Department of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Junke Mou *Department of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Mengyang WangDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Qishuo GuDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Yuehong WangDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Xiaoxuan BaiDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Shan ZhangDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Shengfang WangDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Ying LvDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Xiuzhu WengDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Xiaolin LiuDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Man LiDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Xingtao HuangDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Chen ZhaoDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Ming ZengDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Minghao LiuDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Sheng QuDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Qianhui SunDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Sining HuDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China.
Bo YuDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China. yubodr@163.com.
Haibo JiaDepartment of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China. jhb101180@163.com.

Funding

National Natural Science Foundation of China 82425030
6 · The paper itself

Abstract

backgroundSmoking is considered as the major risk factor for the progression of atherosclerosis (AS), whereas the underlying immunological mechanism remains unclear.

methodsApoE

resultsCigarette tar significantly aggravated the development of atherosclerotic lesion in ApoE

conclusionsCigarette tar augments the expression of MHC II in ECs via promoting CIITA nuclear translocation and PRMT5-mediated methylation modification. This process activates CD4

Indexed as

AtherosclerosisCD4-Positive T-LymphocytesEndothelial CellsHistocompatibility Antigens Class IINuclear ProteinsSmokingTrans-ActivatorsAnimalsHistonesHumansLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, KnockoutHistocompatibility Antigens Class IIHistonesMHC class II transactivator proteinNuclear ProteinsTrans-ActivatorsAntigen presentationAtherosclerosisCD4+Gzma+ T cellsCigarette tarEndothelial cellsSymmetrical dimethylation

Identifiers

PMID42237295
PMCPMC13464332

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.