Evidence map›Paper›PMID 42237409›Full record

ArticleMicrobiome2026

Multi-omics characterization of the skin microbiota reveals the anti-aging roles of Stenotrophomonas maltophilia.

Danni Guo, Yuanyuan Chen, Yahong Wu, Jingmin Cheng, Yawen Lin, Wenjie Lai, Wentao Ma, Hang Yang, Lianyi Han, Lan Ma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Danni Guo *Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Yuanyuan Chen *Shanghai Jahwa United Co., Ltd., Shanghai, 200082, China.
Yahong Wu *Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Jingmin ChengShenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Yawen LinShenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Wenjie LaiDepartment of Urology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, China.
Wentao MaShenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Hang YangShenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Lianyi HanGreater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences, Fudan University, Shanghai, 200433, China.
Lan MaShenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Haidong JiaShanghai Jahwa United Co., Ltd., Shanghai, 200082, China. jiahaidong@jahwa.com.cn.
Xiao LiuShenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. liuxiao@sz.tsinghua.edu.cn.

Funding

Scientific Research Start-up Funds QD2021005NShenzhen Science and Technology Program WDZC20220819134430002
6 · The paper itself

Abstract

backgroundShifts in the skin microbiome have shown a close link to chronological age. However, the contribution of the skin microbiome in skin-aging phenotypes remains unclear.

resultsTo explore this, we performed phenotypic, metabolomic, metagenomic, and functional analyses on a cohort with divergent skin-aging phenotypes. Genome-scale metabolic models (GEMs) integrated with metabolomic analysis revealed that Stenotrophomonas maltophilia, enriched in the younger group (categorized by AI-predicted age and skin elasticity), utilizes the glutathione cycle to maintain redox homeostasis. Cellular experiments showed its metabolites enhanced GSH synthesis and alleviated oxidative-stress-induced phenotypic skin-aging by upregulating key genes in fibroblasts, including GCLM, PGD, SOD2, and NQO1. In addition, GEMs highlighted its potential in maintaining youthful skin phenotypes through the regulation of host metabolic pathways involving betaine, lysolecithin, and porphyrin. In parallel, Acinetobacter guillouiae was found to influence host melanin metabolism by degrading dopamine (DA) and 3-methoxytyramine (3-MT), offering potential therapeutic strategies for mitigating pigmentation.

conclusionsOur findings highlight the dynamic interplay between skin microbiota and the host in phenotypic skin-aging, offering new insights for designing interventions to maintain youthful skin. Video Abstract.

Indexed as

SkinSkin AgingSkin MicrobiomeStenotrophomonas maltophiliaAcinetobacterFibroblastsGlutathioneHumansMelaninsMetabolic Networks and PathwaysMetabolomicsMetagenomicsMultiomicsOxidative StressPhenotypeGlutathioneMelaninsHost-microbiome interactionsMulti-omicsSkin agingSkin microbiomeStenotrophomonas maltophilia

Identifiers

PMID42237409
PMCPMC13449706

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.