Evidence map›Paper›PMID 42237658›Full record

ArticleMuscle & nerve2026

Neuroprotective Effects of RNS60 in TDP-43 Pathology-Associated Amyotrophic Lateral Sclerosis.

Danny R Vesevick, Supurna Ghosh, Andreas Kalmes, P Hande Ozdinler, Mukesh Gautam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Danny R VesevickDavee Department of Neurology and Clinical Neurological Sciences, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Supurna GhoshRevalesio, Tacoma, Washington, USA.
Andreas KalmesRevalesio, Tacoma, Washington, USA.ORCID https://orcid.org/0009-0000-0715-5652
P Hande OzdinlerDavee Department of Neurology and Clinical Neurological Sciences, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Mukesh GautamDavee Department of Neurology and Clinical Neurological Sciences, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-6595-3051

Funding

A Long SwimQueen B FoundationRevalesio
6 · The paper itself

Abstract

introductionTDP-43 pathology is broadly observed in the cerebral cortex of patients with amyotrophic lateral sclerosis (ALS). RNS60, an experimental treatment for acute ischemic stroke and ALS, enhanced mitochondrial biogenesis and function in other preclinical models. We investigated whether RNS60 improved mitochondrial stability and upper motor neuron (UMN) health in a TDP-43 mouse model of ALS.

methodsprpTDP-43

resultsRNS60 treatment reduced defective mitochondria in UMNs (prpTDP-43 DISCUSSION: These results suggest that RNS60 treatment promotes motor neuron health in ALS by protecting mitochondrial structure and function, preserving NMJ integrity, and reducing gliosis.

Indexed as

Amyotrophic Lateral SclerosisDNA-Binding ProteinsNeuroprotective AgentsAnimalsDisease Models, AnimalFemaleGreen Fluorescent ProteinsMaleMiceMice, TransgenicMitochondriaMotor NeuronsMuscle, SkeletalNeuromuscular JunctionSpinal CordDNA-Binding ProteinsGreen Fluorescent ProteinsNeuroprotective AgentsTardbp protein, mouse

Identifiers

PMID42237658
PMCPMC13332579

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.