SynthesisPain research & management2026
Pharmacological Therapies for Pain Management in Patients With Amputation: A Systematic Review and Network Meta-Analysis.
Synthesis in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Pharmacological Therapies for Pain Management in Patients With Amputation: A Systematic Review and Network Meta-Analysis.Pain research & management · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the efficacy and safety of pharmacological therapies for pain management in postamputation patients through a systematic review and network meta-analysis of existing evidence.
methodsThis systematic review and network meta-analysis (NMA) was conducted following the PRISMA-NMA guidelines and registered in PROSPERO (CRD42024500600). In September 2024, two independent reviewers searched the Cochrane Library, LILACS, PubMed/MEDLINE, SciELO, ScienceDirect, Web of Science, Scopus, CINAHL, and Google Scholar. The eligibility criteria included systematic reviews (with or without meta-analysis) evaluating pharmacological interventions in populations aged 18 years or older.
resultsSeventeen studies met the inclusion criteria and were described in narrative form. Among these studies, seven systematic reviews of randomized clinical trials contained data suitable for NMA. Two primary outcomes were assessed: residual limb pain and phantom limb pain. Analysis of the three subnetworks revealed no statistically significant differences in either direct or indirect comparisons across the evaluated therapies.
conclusionCurrent evidence is insufficient to support the efficacy and safety of specific pharmacological therapies for pain management in patients with amputation compared to placebo or alternative treatments.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.