Evidence map›Paper›PMID 42238238›Full record

ReviewFrontiers in endocrinology2026

Altered mitochondrial functionality in metabolic disorders: insights from

Yunlin Zeng, Yang Yang, Yuao Zhu, Peixin Xu, Chakin Cheong, Yong Juan Zhao, Gyeong Hun Baeg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunlin ZengFaculty of Health Sciences, University of Macau, Taipa, Macao SAR, China.
Yang YangFaculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Yuao ZhuFaculty of Health Sciences, University of Macau, Taipa, Macao SAR, China.
Peixin XuFaculty of Health Sciences, University of Macau, Taipa, Macao SAR, China.
Chakin CheongFaculty of Health Sciences, University of Macau, Taipa, Macao SAR, China.
Yong Juan ZhaoCiechanover Institute of Precision and Regenerative Medicine, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Gyeong Hun BaegFaculty of Health Sciences, University of Macau, Taipa, Macao SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathophysiological association between obesity and type 2 diabetes (T2D) increasingly highlights the central role of mitochondrial dysfunction. As critical signaling hubs orchestrating metabolism, mitochondria are pivotal in maintaining metabolic homeostasis. Imbalances in mitochondrial quality control mechanisms lead to an accumulation of damaged mitochondria with abnormal dynamics and functions, exacerbating the progression of obesity, insulin resistance, and T2D. Although therapeutic interventions for obesity and T2D have shown promise, they remain insufficient for achieving sustained remission from obesity and T2D on a global scale. Furthermore, existing rodent models often struggle to fully recapitulate human metabolic disorders due to species-specific metabolic differences and technical limitations.

Indexed as

Disease Models, AnimalDrosophila melanogasterMetabolic DiseasesMitochondriaAnimalsDiabetes Mellitus, Type 2HumansInsulin ResistanceObesityDrosophila melanogastermitochondrial dysfunctionmitochondrial quality controlmitophagyobesity and type 2 diabetes

Identifiers

PMID42238238
PMCPMC13225985

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.