Evidence map›Paper›PMID 42238433›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Prevalence, Genetics, and Imaging Characteristics of Patients with Mitral Valve Prolapse and Arrhythmogenic Right Ventricular Cardiomyopathy.

Amy Rich, Lionel Tastet, Luca Cristin, Rohit Jhawar, Janet J Tang, Melvin Scheinman, Francesca N Delling

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amy RichDepartment of Medicine, Cardiovascular Division, University of California, San Francisco (UCSF), California, USA.
Lionel TastetDepartment of Medicine, Cardiovascular Division, University of California, San Francisco (UCSF), California, USA.
Luca CristinDepartment of Medicine, Cardiovascular Division, University of California, San Francisco (UCSF), California, USA.
Rohit JhawarDepartment of Medicine, Cardiovascular Division, University of California, San Francisco (UCSF), California, USA.
Janet J TangDepartment of Medicine, Cardiovascular Division, University of California, San Francisco (UCSF), California, USA.
Melvin ScheinmanDepartment of Medicine, Cardiovascular Division, University of California, San Francisco (UCSF), California, USA.
Francesca N DellingDepartment of Medicine, Cardiovascular Division, University of California, San Francisco (UCSF), California, USA.

Funding

Prospective sudden cardiac death risk stratification using CMR and echocardiography machine learning in mitral valve prolapseR01HL153447 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DELLING, FRANCESCA N · 2020 to 2024
$4.7M
NHLBI NIH HHS R01 HL153447
6 · The paper itself

Abstract

Background: Concomitant arrhythmogenic right ventricular cardiomyopathy (ARVC) and mitral valve prolapse (MVP) has only been described in case reports. Little is known about genetic and phenotypic characteristics of these patients. Objective: To describe the prevalence, genetics, and imaging characteristics of MVP in ARVC patients. Methods: We identified 111 definite ARVC cases through medical record review, arrhythmia/cardiomyopathy targeted gene panels, and contrast cardiac magnetic resonance data. MVP was diagnosed on echocardiography as mitral leaflet displacement >2 mm above the annular plane in systole, "borderline MVP" defined as ≤2 mm. Results: We found MVP/borderline MVP in 14% of ARVC patients. Cardiac arrest occurred in 20% of those with MVP/borderline MVP compared to 16% without valve abnormalities. Among 69 ARVC patients with identified genetic variants, Conclusions: MVP is prevalent in ARVC and characterized by

Indexed as

arrhythmogenic right ventricular cardiomyopathybiventricular cardiomyopathymitral valve prolapsePKP2ventricular arrhythmias

Identifiers

PMID42238433
PMCPMC13228771

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.