In one paragraphArticle in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
40 authors.
Sarah Mc ColbertDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3060-7471 Shane O'ConnellDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-1693-9157 Howard J EdenbergDepartment of Biochemistry, Molecular Biology and Pharmacology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-0344-9690 Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-0394-777X Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6137-5699 Zuriel CejaBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0003-2392-1964 Seonggyun HanDepartment of Psychiatry, University of Utah, Salt Lake City, UT, USA.
Vladimir VladimirovDepartment of Psychiatry, The University of Arizona, Phoenix, AZ, USA.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-7772-3264 Gabriel R FriesDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-5468-2612 Marie E GainePharmaceutical Sciences and Experimental Therapeutics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-9196-0028 Jose Guzman-ParraUnidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina - IBIMA Plataforma Bionand, Málaga, Spain.ORCID 0000-0002-1463-6435 Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450 Divya MehtaCentre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0002-7359-348X John I NurnbergerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-7674-1767 Mallory StephensonDepartment of Cellular, Molecular, and Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0002-1498-4333 Fabian StreitHector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0003-1080-4339 Alja Videtic PaskaFaculty of Medicine, Institute of Biochemistry and Molecular Genetics, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0002-1182-5417 Suicide Working Group of the Psychiatric Genomics Consortium
Nathan A KimbrelVA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA.ORCID 0000-0001-7218-1005 Douglas RuderferCenter for Digital Genomic Medicine, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-2365-386X Alexander S HatoumDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-8002-7267 Niamh MullinsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-8021-839X Funding
2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4M1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5M7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3M5/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124873 · NIMH · CARDIFF UNIVERSITY · PI LEWIS, CATHRYN, O'DONOVAN, MICHAEL · 2021 to 2025
$2.6MEstablishing the Suicide Working Group of the Psychiatric Genomics Consortium to elucidate the genetics and biology of suicide outcomesR01MH132733 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Niamh Mullins · 2024 to 2026
$2.4M4/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124847 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M, SEBAT, JONATHAN · 2021 to 2025
$2.1MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M3/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124839 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANDREASSEN, OLE A, HUCKINS, LAURA MARIANNE · 2021 to 2025
$2.0MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M6/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124875 · NIMH · TRINITY COLLEGE DUBLIN · PI Aiden Peter Corvin · 2021 to 2026
$765kNIDA NIH HHS R01 DA054869NIH HHS S10 OD018522NIH HHS S10 OD026880NIMH NIH HHS R01 MH124839NIMH NIH HHS R01 MH124847NIMH NIH HHS R01 MH124851NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH124873NIMH NIH HHS R01 MH124875NIMH NIH HHS R01 MH132733
6 · The paper itselfAbstract
Suicidality phenotypes, including suicidal ideation (SI), non-fatal suicide attempt (SA), and suicide death (SD), are heritable and exhibit both shared and phenotype-specific genetic influences. Using genomic structural equation modelling, we estimated the shared genetic architecture across GWAS of SI (176,147 cases, 1,010,300 controls), SA (53,919 cases, 1,063,988 controls), and SD (7,584 cases, 652,070 controls) and conducted a multivariate GWAS of a latent suicidality factor capturing their shared liability. This analysis identified 36 genome-wide significant loci, including seven not previously reported in any suicidality GWAS. Follow-up analyses identified residual genetic variance specific to each phenotype, including three SD-specific genomic risk loci. Conditioning suicidality phenotypes on genetic liability to psychiatric disorders revealed significant residual genetic variance across SI, SA, SD, and the suicidality common factor. Together, these results suggest that suicidality reflects both shared genetic liability and phenotype-specific contributions.
Identifiers
PMID42238468
PMCPMC13228751
What Socratic holds
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