Evidence map›Paper›PMID 42238477›Full record

ArticleBrain communications2026

Quantitative susceptibility mapping demonstrates ageing-related long-term structural brain changes in adult rats after mild ischaemic stroke.

Zuitian Tao, Charlotte M Ermine, David K Wright, Mohamed Salah Khlif, Vanessa H Brait, Lachlan H Thompson, Leigh A Johnston, Amy Brodtmann, Warda T Syeda

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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zuitian TaoDepartment of Biomedical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
Charlotte M ErmineThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3010, Australia.
David K WrightThe Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.ORCID https://orcid.org/0000-0002-7535-8651
Mohamed Salah KhlifCognitive Health Initiative, School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Vanessa H BraitThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3010, Australia.
Lachlan H ThompsonThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3010, Australia.ORCID https://orcid.org/0000-0003-2632-0304
Leigh A JohnstonDepartment of Biomedical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
Amy BrodtmannCognitive Health Initiative, School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.
Warda T SyedaMelbourne Brain Centre Imaging Unit, The University of Melbourne, Parkville 3010, Victoria, Australia.ORCID https://orcid.org/0000-0001-6294-622X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantitative susceptibility mapping is a novel, non-invasive MRI technique that measures tissue magnetic susceptibility, offering insights into brain iron, calcium and myelin distribution. Here, we used quantitative susceptibility mapping to assess whole-brain long-term susceptibility changes in adult rats following endothelin-1-induced mild focal stroke in the right motor cortex over 48 weeks. No significant differences in susceptibility trajectories were found between stroke and sham groups in either hemisphere. However, both groups exhibited shared regional susceptibility changes, likely age-related, reflecting variations in iron, calcium, or white matter myelination over time. These findings provide a new perspective on ageing effects on brain metal accumulation and structural integrity, highlighting the need for further histological validation to clarify underlying mechanisms.

Indexed as

brainMRIquantitative susceptibility mappingrat modelsstroke

Identifiers

PMID42238477
PMCPMC13228143

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.