Evidence map›Paper›PMID 42238478›Full record

ArticleBrain communications2026

Clinicoanatomic localization of iron-rich gliosis in aphasic presentations of globular glial tauopathy.

David J Irwin, Sheina Emrani, Daniel T Ohm, Winifred Trotman, Alejandra Bahena, Eric Teunissen-Bermeo, Philip Sabatini, Sandhitsu R Das, Gabor Mizsei, Karthik Prabhakaran and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

David J IrwinDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-5599-5098
Sheina EmraniDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniel T OhmDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-7930-5434
Winifred TrotmanDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alejandra BahenaDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eric Teunissen-BermeoDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Philip SabatiniDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sandhitsu R DasDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gabor MizseiDepartment Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Karthik PrabhakaranDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ranjit IttyerahDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
H Branch CoslettDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lauren MassimoDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
David A WolkDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
John A DetreDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
James C GeeDepartment Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Edward B LeePathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-4589-1180
Paul YushkevichDepartment Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0001-8543-4016
Corey T McMillanDepartment Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
M Dylan TisdallDepartment Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-0454-3112

Funding

Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
Ex Vivo Imaging of the Aging Brain to Discover Morphology/Pathology AssociationsR01AG056014 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Paul A. Yushkevich · 2017 to 2026
$4.5M
Improving the sensitivity and specificity of MRI-based biomarkers in Alzheimer's diseaseR01AG069474 · NIA · UNIVERSITY OF PENNSYLVANIA · PI WOLK, DAVID A, YUSHKEVICH, PAUL A. · 2024 to 2025
$1.4M
NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG056014NIA NIH HHS R01 AG069474
6 · The paper itself

Abstract

Globular glial tauopathy is a 4-repeat tauopathy associated with heterogenous clinical syndromes, including primary progressive aphasia. Iron-reactive gliosis in mid-to-deep cortical layers has previously been reported in this disorder, but detailed anatomic localization and its relationship to clinical symptoms is understudied, particularly within the anatomic framework of primary progressive aphasia. In a series of five autopsy-confirmed patients with globular glial tauopathy and one healthy control, we utilize ultra-high-resolution whole-hemisphere

Indexed as

globular glial tauopathyironMRIneuroinflammationprimary progressive aphasia

Identifiers

PMID42238478
PMCPMC13227947

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.