Histamine in Diabetic Cardiovascular Complications.

Shanshan Hu, Gaofeng Zeng, Yao Tang, Qun Wang, Jianfeng Wu, Xiangdong Yang

Abstract readReview

In one paragraph

Review in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shanshan HuClinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421002 Hengyang, Hunan, China.ORCID https://orcid.org/0009-0007-7072-8901

Gaofeng ZengClinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421002 Hengyang, Hunan, China.ORCID https://orcid.org/0009-0001-4374-3889

Yao TangClinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421002 Hengyang, Hunan, China.

Qun WangClinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421002 Hengyang, Hunan, China.

Jianfeng WuClinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421002 Hengyang, Hunan, China.

Xiangdong YangShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.ORCID https://orcid.org/0000-0002-4201-7017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic cardiovascular complications are the primary cause of diabetes-associated mortality. The pathogenesis of diabetic cardiomyopathy is complex; the main clinical manifestations include inflammation, hyperinsulinemia, mitochondrial dysfunction, endoplasmic reticulum stress, and coronary microcirculation disorders. Among these factors, inflammatory responses play a pivotal role in diabetic cardiomyopathy. The accumulation of histamine secreted by macrophages in multiple tissues of patients with diabetes mellitus is crucial for the onset and progression of the disease, particularly diabetic cardiovascular complications. Histamine and associated receptor-mediated signaling pathways are implicated in diabetic cardiovascular complications; however, the specific mechanisms remain unclear and warrant further investigation.

Indexed as

diabetic cardiomyopathyH1Rhistamine

Identifiers

PMID42238635

DOI10.31083/RCM47801

PMCPMC13227364

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.